The Compatibility Gene is a scientific adventure story set in a new field of genetic discovery – that of the crucial genes that define our relationships, our health and our individuality. Here, Daniel M Davis, one of the leading scientists in the field, tells us the story of its grounbreaking developments that have the potential to change us all
We each possess a similar set of around 25,000 human genes. Yet a tiny, distinctive cluster of these genes plays a disproportionately large part in how our bodies work. These few genes, argues Daniel M. Davis, hold the key to who we are as individuals and our relationship to the world: how we combat disease, how our brains are wired, how attractive we are, even how likely we are to reproduce.
In The Compatibility Gene, one of our foremost immunologists tells the remarkable history of these genes' discovery and the unlocking of their secrets. From the British scientific pioneers who, during the Second World War, struggled to understand the mysteries of transplants and grafts, to the Swiss zoologist who devised an entirely new method of assessing potential couples' compatibility based on the smell of worn T-shirts, Davis traces what is nothing less than a scientific revolution in our understanding of the human body: a global adventure spanning some sixty years.
Davis shows how the compatibility gene is radically transforming our knowledge of the way our bodies work – and is having profound consequences for medical research and ethics. Looking to the future, he considers the startling possibilities of what these wondrous discoveries might mean for you and me.
Daniel M. Davis is director of research at the University of Manchester's Collaborative Centre for Inflammation Research and a visiting professor at Imperial College, London. He has published over 100 academic papers, including papers in Nature and Science, and Scientific American, and lectures all over the world, including at the Royal Institution. He has previously won the Oxford University Press Science Writing Prize, and has given numerous interviews for national and international media, including the Times, Guardian, Metro, and National Public Radio (USA). A major feature on his research was published in The Times. Experiments filmed in his laboratory were shown in the BBC series The History of Medicine (2008). He also keenly engages in broad scientific affairs, recently publishing a view on UK science funding policies in Nature.
"Who am I? What makes me different from everyone else? Daniel Davis recounts the remarkable science that has answered one version of these questions"
– Steven Pinker
"An elegantly written, unexpectedly gripping account of how scientists painstakingly unravelled the way in which a small group of genes crucially influence, and unexpectedly interconnect, various aspects of our lives [...] Lab work has rarely been made to seem more interesting or heroic"
– Bill Bryson, Guardian, books of the year
"The genes that make you a true individual Davis provides a well-written and easy-to-read account of the sometimes complicated biology behind the crucial genes that affect our lives so profoundly"
– Mark Viney, New Scientist
"Davis examines the discovery and significance of the compatibility genes – genes that simply label you as you he weaves a warm biographical thread through his tale of scientific discovery"
– Nicola Davis, The Times
"Enlightening [...] extraordinary [...] a fascinating, expertly told story"
– Michael Brooks, New Statesman
"What scores is his humanity and the wonderful pen-portraits of the many scientists involved in this fast-moving field [...] 5 out of 5 stars"
– Henry Gee, BBC Focus
"There aren't many stories of scientific endeavour that have never been told. This is one of them. Ostensibly about a set of genes that we all have and need, this book is really about the men and women who discovered them and worked out what they do. It's about brilliant insights and lucky guesses; the glory of being proved right and the paralysing fear of getting it wrong; the passion for cures and the lust for Nobels. It's a search for the essence of scientific greatness by a scientist who is headed that way himself"
– Armand Marie Leroi, author of Mutants