335 pages, 69 colour & 8 b/w illustrations, 25 colour tables
Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans (~75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally).
Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes.
The contributors to The Rights and Wrongs of Zebrafish are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.
Chapter 1. Mutagenesis and transgenesis in zebrafish - Fabienne E. Poulain
Chapter 2. Developing zebrafish depression-related models - Julian Pittman and Angelo Piato
Chapter 3. Zebrafish models of anxiety-like behavior - Adam D. Collier, Allan V. Kalueff and David J. Echevarria
Chapter 4. Assessing cognitive phenotypes in zebrafish - David J. Echevarria, Adam D. Collier and Elizabeth A. Lamb
Chapter 5. Social phenotypes in zebrafish, Rita Nunes, Nathan Ruhl, Svante Winberg and Rui F. Oliveira
Chapter 6. Modeling OCD endophenotypes in zebrafish - Matthew Parker
Chapter 7. Zebrafish models of attention-deficit/hyperactivity disorder (ADHD) - William Norton, Merlin Lange, Laure Bally-Cuif and Klaus-Peter Lesch
Chapter 8. Zebrafish neurotoxicity models - Julian Pittman
Chapter 9. Sleep phenotypes in zebrafish - David J. Echevarria and Kanza M. Khan
Chapter 10. Zebrafish neurobehavioral assays for drug addiction research - Henning Schneider
Chapter 11. Zebrafish behavioral models of ageing - Alistair J. Brock, Ari Sudwarts, Matthew O. Parker and Caroline H. Brennan
Chapter 12. Integrating morphological and behavioral phenotypes in developing zebrafish - Guozhu Zhang, Lisa Truong, Robert L. Tanguay and David M. Reif
Chapter 13. Neuroimaging phenotypes in zebrafish - Jeremy F. P. Ullmann and Andrew L. Janke
Chapter 14. Illustrated zebrafish neurobehavioral glossary - Allan V. Kalueff and the Zebrafish Neuroscience Research Consortium (ZNRC)
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Allan V. Kalueff is Professor of Translational Biomedicne at St. Petersburg State University.