Offers thorough, cutting-edge coverage of the field, ranging from the history of cell death science to its modern methodology. This new edition features relevant discussion of: the impact of genomics and proteomics; gene therapy and pharmacogenetics; the role of mitochondria; caspase-independent and non-apoptotic cell death; evolution of mechanisms.
...thoughtfully edited and readable. The book illustrates the importance of apoptosis in development, homeostasis, and human disease...an important contribution to the literature. (Doody's Book Review Service) "...thoroughly researched, highly readable, and informative." (E-STREAMS, March 2005)
Contributors.Preface.SECTION I: CELL DEATH ORIGIN AND PROGRESSION.1. Introduction (R. Lockshin & Z. Zakeri).SECTION II: BIOLOGICAL ROLE OF CELL DEATH IN DEVELOPMENT AND HOMEOSTASIS.2. Cell Death: Shaping an Embryo (Z. Zakeri & R. Lockshin).3. Cell Death in Dictyostelium: Assessing a Genetic Approach (J. Levraud, et al.).4. Programmed Cell Death in Drosophila Melanogaster (L. Dorstyn & S. Kumar).5. Cell Death in Plant Development and Defense (R. Mittler & A. Cheung).6. Regulation of Apoptosis by Extracellular Matrix during Postembryonic Development in Xenopus Laevis (A. Ishizuya-Oka, et al.).7. Apoptosis in the Immune System (A. Bras, et al.).8. Cell Death in Neuronal Development and Maintenance (A. Tolkovsky, et al.).9. Cell Turnover: Intestines and Other Tissues (J. Wilson & C. Potten).10. Cell Death, Aging Phenotypes, and Models of Premature Aging (H. Warner).SECTION III: HOW CELL DEATH IS CARRIED OUT.11. Survival Factors (D. Vaux).12. Caspase-Independent and Autophagic Programmed Cell Death (W. Bursch, et al.).13. The Recognition and Engulfment of Apoptotic Cells by Phagocytes (R. Birge).14. Cell Cycle Genes: pRb and p53 (N. Sang & A. Giordano).15. Mitochondria and Oxidation in the Regulation of the Cell Death (J. Robertson, et al.).SECTION IV: DEREGULATION OF CELL DEATH IN DISEASE AND FUTURE INTERVENTION.16. The Use of Proteomics to Identify and Characterize Cell Death Proteins (X. Saelens, et al.).17. Cell Death in Viral Infections (Y. Chen, et al.).18. Cell Death in Cancer and Cancer Therapy (S. Fulda & K. Debatin).19. The Role of Apoptosis in Myocardial Infrarction and Heart Failure (K. Mani, et al.). Index.
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There are now over 100,000 publications on cell death. This book attempts to guide researchers at all levels by providing expert evaluation of the physiological and pathological expression of apoptosis throughout the animal and plant kingdoms; the primary mechanisms of how cell deaths are carried out, the impact of cell death on disease, and the potential for manipulating cell death for therapeutic goals. The authors have attempted to provide a viewpoint broad enough to render the work accessible to advanced students and beginning researchers, and yet profound enough that those with more extensive backgrounds will find the contributions valuable. Scientists at all levels will find in this book a breadth and overview of apoptosis and programmed cell death that is unavailable elsewhere. - Dr. Richard Lockshin, Department of Biological Sciences, St. John's University "This update of When Cells Die provides an introduction to apoptosis for advanced undergraduates, graduate students, and professionals in many life sciences fields, and covers the most recent discoveries and theories, including proteomics and potential for exploiting or regulating apoptosis for therapeutic purposes. It is fully referenced and illustrated, and will be a valuable asset as a laboratory, medical, or teaching resource, and may serve as a text for courses on cell death and apoptosis." - Dr. Zahra Zakeri, Department of Biology, Queens College and Graduate Center of the City University of New York