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Signalling within and between cells is one of the most important aspects of modern biochemistry and cell biology. An understanding of signalling pathways is vital to a wide range of biologists, from those who are investigating the causes of cancer, to those who are concerned about the impact of environmental pollutants on the ecosystem. The way cells adapt to changing environments, and the way cell dysfunction causes disease, is underpinned by cell signalling events.
Cell Signalling presents a carefully structured and highly accessible introduction to this intricate and rapidly growing field. Starting with an overview of cell signalling and highlighting its importance in many biological systems, Cell Signaling goes on to explore the key components of extracellular and intracellular signalling mechanisms, before examining how these components come together to create signalling pathways. A focus on common components and concepts, rather than mechanistic detail, allows the reader to gain a thorough understanding of the principles that underpin cell signalling.
New to this Edition:
- New full colour diagrams help students to visualize the key concepts explained in the text more effectively
- Case Studies explore pieces of research that have been particularly valuable in elucidating different aspects of cell signalling and the impact of the experimental approaches used
- What next? sections highlight exciting new areas of research in cell signalling, fostering thought and discussion
- A series of online Journal Clubs encourage students to read and evaluate the primary research literature
Part 1: An overview of signalling
1: Aspects of cellular signalling
2: Pathways are the key to signalling
3: A look at some of the history and techniques of cell signalling
Part 2: Components that comprise signalling pathways
4: Extracellular signals: hormones, cytokines and growth factors
5: Detection of extracellular signals: the role of receptors
6: Protein phosphorylation, kinases and phosphatases
7: Cyclic nucleotides, cyclases and G proteins
8: Inositol phosphate metabolism and roles of membrane lipids
9: Intracellular calcium ions: control of their concentrations and roles in signalling
10: Reactive oxygen species, reactive nitrogen species and redox signalling
Part 3: Selected examples of signalling pathways and events
11: Insulin and the signal transduction cascades it invokes
12: Perception of the environment
13: Signalling in development and for the regulation of gene expression
14: Life, death and apoptosis
Part 4: Final thoughts
15: Cell signalling: importance, complexity and the future
John Hancock is Professor of Cell Signalling at the University of the West of England. He has had a long standing interest in cell signalling and redox biology, and tries to bring these together as much as possible in his research. In addition to Cell Signalling he has published several reviews on nitric oxide and reactive oxygen species, and most recently on hydrogen sulfide.
"A good overview of the key underlying concepts and principles, allowing students to gain a solid grounding in the subject. I like the Case Study sections which link to research findings; these provide relevant context and help students to understand the key message in complex scientific articles."
– Dr Andrew Chantry, University of East Anglia
"It is really the best specialist text for undergraduates on this topic I have seen."
– Dr Fergus Doherty, University of Nottingham
Reviews from previous editions:
"John Hancock's Cell Signalling is a straightforward introduction to a rapidly expanding field of biology. Its unintimidating writing style, simple and uncluttered figures, and competitive price make it a wonderful introductory text for undergraduates."
– Dr Laura K. Palmer, Penn State University
"Complexity and specificity are the hallmarks of cell signalling, yet Hancock in this third edition has gone a long way to simplify these complicated processes. His signalling examples are clever and well-conceived, his writing descriptive and his passion for his subject infectious [...] this is marvellous value for money and is a worthy companion to an undergraduate/postgraduate reference library."
– John P. Phelan, Waterford Institute of Technology, Ireland in The Biochemist