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Gives an overview of how emerging genomic and proteomic technologies are making significant contributions to global drug discovery programs, and in particular the key role that comparative genomics and proteomics play within this strategy. Each chapter is written by respected authorities, with hands-on experience, from both academic and pharmaceutical backgrounds.
1. Comparative Genomics and Drug Discovery in Trypanosomatids
2. The Practical Implications of Comparative Kinetoplastid Genomics
3. The Relevance of Host Genes in Malaria
4. Nicotinic Acetylcholine Receptors as Drug/Chemical Targets, Contributions from Comparative Genomics, Forward and Reverse Genetics
5. Discovery of Novel Sodium Channel Inhibitors - A Gene Family-Based Approach
6. 'Omics' in Translational Medicine : Are They Lost in Translation?
7. Drug-Target Discovery In Silico: Using the Web to Identify Novel Molecular Targets for Drug Action