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Presents an integrated view of the expression of bacterial genetic information, genome architecture and function, and bacterial physiology and pathogenesis.
This book blends information from the very latest research on bacterial chromosome and nucleoid architecture, whole-genome analysis, cell signalling, and gene expression control with well-known gene regulation paradigms from model organisms (including pathogens) to give readers a picture of how information flows from the environment to the gene, modulating its expression and influencing the competitive fitness of the microbe.
Structure and Function of the Bacterial Genome explores the governance of the expression of the genes that make a bacterium what it is, and updates the basics of gene expression control with information about transcription promoter structure and function, the role of DNA as a regulatory factor (in addition to its role as a carrier of genetic information), small RNAs, RNAs that sense chemical signals, ribosomes and translation, posttranslational modification of proteins, and protein secretion. It looks at the forces driving the conservation and the evolution of the dynamic genome and offers chapters that cover DNA replication, DNA repair, plasmid biology, recombination, transposition, the roles of repetitive DNA sequences, horizontal gene transfer, the defence of the genome by CRISPR-Cas, restriction enzymes, Argonaute proteins and BREX systems. The book finishes with a chapter that gives an integrated overview of genome structure and function.
- Blends knowledge of gene regulatory mechanisms with a consideration of nucleoid structure and dynamics
- Offers a 'DNA-centric' approach to considering transcription control
- Views horizontal gene transfer from a gene regulation perspective
- Assesses the opportunities and limitations of designing synthetic microbes or rewiring existing ones
Structure and Function of the Bacterial Genome is an ideal book for graduate and undergraduate students studying microbial cell biology, bacterial pathogenesis, gene regulation, and molecular microbiology. It will also appeal to principal investigators conducting research on these and related topics and researchers in synthetic biology and other arms of biotechnology.
Preface xiii
1 The Bacterial Genome – Where the Genes are 1
2 Conservation and Evolution of the Dynamic Genome 67
3 Gene Control: Transcription and Its Regulation 113
4 Gene Control: Regulation at the RNA Level 133
5 Gene Control: Regulation at the Protein Level 149
6 Gene Control and Bacterial Physiology 175
7 Gene Control: Global Regulation by H-NS 211
8 An Integrated View of Genome Structure and Function 231
References 247
Index 379
Charles J. Dorman, PhD, ScD, MRIA has held the established chair of Microbiology at Trinity College Dublin, Ireland since 1994. Previously, he held a Royal Society University Research Fellowship at the Biochemistry Department in Dundee University, UK, where he was also a Lecturer in Biochemistry. Professor Dorman is a former Editor-in-Chief of Microbiology, is a Trustee and Council member of the Microbiology Society and has served as the Ambassador to Western Europe of the American Society for Microbiology. He is a founding member of the European Academy of Microbiology, a Fellow of the American Academy of Microbiology, a Fellow of the Royal Society of Biology and a Member of the Royal Irish Academy.
