Studies in Natural Products Chemistry, Volume 12 Stereoselective Synthesis Part H

About this book

The plant kingdom offers a vast largely untapped source of a wide diversity of organic compounds, potentially useful in medicine. With the advent of powerful spectroscopic techniques and improved separation procedures it is now possible to elucidate the structures of compounds isolated in sub-milligram quantities. There has accordingly been a significant increase in the number of new compounds reported in the literature during the last decade. However, efforts at bioassay-directed fractionation of plant extracts have lagged behind, largely due to the absence of pharmacological screens in most laboratories involved in phytochemical researches. The present volume contains contributions from a number of leading natural product chemists. The syntheses of the avermectin-milbemycin family of antiparasitic agents, macrolide antibiotics, beta-lactam antibiotics, beta-methylcarbapenem derivatives, taxane diterpenes and tumour-promoting diterpenes, indolizidines and indol(2,3-a)carbazole alkaloids, 2-amino alcohols are described. Moreover, one contribution deals with the generation of cationic and radical intermediates for synthesis of natural products. Volume 12, containing in-depth reviews by eminent exponents of the art of organic synthesis, will no doubt generate the same interest and excitement as other previous volumes of this series.

Contents

Foreword, K. Nakanishi; contributors, synthetic routes to the oxahydrindene subunit of the avermectin-milbemycin family of antiparasitic agents - a review, S.A. Peak, A.B. Smith; a new tandem process and its application to the syntheses of macrolide antibiotics, M. Nakata, K. Tatsuta; stereoselective synthetic and mechanistic chemistry of bicyclomycin, R.M. Williams; the role of isocyanides in the synthesis of beta-lactam antibiotics and related compounds, H. Eckert, I. Ugi; synthesis of the beta-methylcarbapenem key intermediates, Y. Ito, S. Terashima; chemical studies of the taxane diterpenes, C.S. Swindell; recent advances in the synthesis of tumour-promoting diterpenes, J.H. Rigby; hydroxylated indolizidines and their synthesis, J. Cossy, P. Vogel; a survey of indolo(2,3a)carbazole alkaloids and related natural products, G.W. Gribble, S.J. Berthel; synthetic methodology for 2-amino alcohols of biological interest, T. Kunieda, T. Ishizuka; stereoselective synthesis of natural products via cationic and radical intermediates, S. Shibuya, T. Yokomatsu, Y. Yuasa; subject index.

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