Studies in Natural Products Chemistry, Volume 13 Bioactive Natural Products Part A

About this book

Natural products chemistry has evolved with growing emphasis on isolating bioactive natural compounds. The synthetic programmes are also directed towards bioactive natural products, many of which could hitherto only be obtained in small quantities from much larger quantities. However, they can be synthesized in much larger quantitities. Moreover, new analogues may be prepared which will have a higher activity and lower toxicity than the parent compounds. The present volume specifically covers the field of such bioactive natural products. It presents research being carried out on a wide variety of compounds, including oligonucleotides, bioactive terpenes, anti-tumour antibiotics, cytochalasans, indole alkaloids, flavours and biologically active carba-sugars. The in-depth presentations on some of the current frontiers of natural product chemistry should prove to be of wide interest to all organic chemists.

Contents

Synthesis of di- and triquinane sesqui-, di- and sesterterpenes - Columbus style, L.A. Paquette; asymmetric synthesis of bioactive natural products and related compounds from chiral propane-1, 3-diols and analogues, M. Ihara and K. Fukumoto; total synthesis of cytochalasans, E.J. Thomas; synthetic modifications of the erythromycin A macrolactone - effects on biological activity, P.A. Lartey and T.J. Perun; synthesis of biologically active compounds composed of carba-sugars, S. Ogawa; automated synthesis, structure and biological activity of backbone-modified oligonucleotides - the antisense approach, A. Frauendorf and J.W. Engels; new avenues in natural products - strategies in the biogeneration of flavours, C. Fuganti et al; anticancer acridone alkaloids, Tsann-Lone Su and K.A. Watanabe; the synthesis of macroline related indole alkaloids, Yingzhi Bi et al; total synthesis of mitomycins, T. Fukuyama and L. Yang; organosilicon compounds as nucleophiles in the synthesis of bioactive natural products via N-acyliminium intermediates, H. De Koning et al; non-trichothecene secondary metabolites of fusarium - recent work, M.E. Savard and J.W. Apsimon; naturally occurring mevinic acids - synthetic studies, T. Rosen; pharmacognosy - new roots for an old science, G.A. Cordell.

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