608 pages, 729 colour illustrations
Now in its sixth edition, Biochemistry and Molecular Biology provides the perfect balance between detail and conceptual understanding. Maintaining the much-praised clarity of previous editions, this edition incorporates both new techniques and pivotal discoveries in a succinct, easy-to-digest way, using updated figures and diagrams to help explain complex processes.
Updated content on the control of gene expression reflects the increasing emphasis on gene regulation in contemporary research, and incorporates up-to-date discussions of recent developments. Chapter summaries are logically laid out, forming bulleted lists which provide students with a consolidation of difficult concepts and progressively guide them through the specifics whilst keeping the big picture in mind. Additional 'find out more' sections provide helpful problem-solving support and the further reading is divided into types to cater for broader learning needs.
With an integrated approach covering both biochemistry and molecular biology, complemented by frequent diagrams and clear explanations, and all presented in a wider cellular context, this text is the perfect introduction for any student new to the subject.
New to this Edition:
- The opening section has been restructured to enhance understanding of core introductory principles, with greater coverage of basic concepts such as chemical bonding and more worked examples of numerical problems
- Updated content on manipulating DNA and genes, incorporating gene editing and other recent developments in the field
- Entirely updated figures and diagrams are easier to interpret and help explain complex processes
- Summary sections are redesigned to form bulleted lists, providing a consolidation of difficult concepts
- End of chapter questions and additional reading have been re-worked to include more guidance for students and lecturers about their use
- An extended selection of online resources with additional Multiple Choice Questions for each chapter
Review of previous editions:
"Easy to read with good use of simple figures and plenty of internal cross-references to other chapters or relevant pages. I was impressed with the inclusion of some very up to date findings."
– Dr Peter Morris, School of Life Sciences, Heriot-Watt University
"I don't know of any other biology/biochemistry book that explains DNA replication as well as this one"
– Lynn Rogers, School of Molecular and Biomedical Science, Adelaide University
"The style is very clear, logical and systematic. The diagrams complement the text well"
– Dr Momna Hejmadi, Department of Biology and Biochemistry, University of Bath
"Good entry level biochemistry textbook that gives students an overview of the diversity of biochemistry and that introduces abstract concepts in a well-explained and accessible way."
– Dirk Wildeboer, Natural Sciences, Middlesex University
"This textbook presents classical biochemistry material with a balanced emphasis on details and conceptual understanding. Explanations are given in a conversational manner so that students are not distracted by an over-whelming amount of new terminology"
– Amanda Storm, Biology, James Madison University
Part 1: Basic concepts of life
1: The basic molecular themes of life
2: Cells , prokaryotes, eukaryotes and viruses
3: Energy considerations in biochemistry
Part 2: Structure and function of proteins and membranes
4: The structure of proteins
5: Methods in protein investigation
7: The cell membrane and membrane proteins
8: Muscle contraction, the cytoskeleton, and molecular motors
Part 3: Metabolism and Nutrition
9: Principles of nutrition
10: Food digestion, absorption and distribution to the tissues
11: Mechanisms of transport, storage and mobilization of dietary components
12: Principles of energy release from food
13: Glycolysis, the citric acid cycle, electron transport system and oxidative phosphorylation
14: Energy release from fat
15: The pentose phosphate pathway
17: Synthesis of fat and related compounds
18: Nitrogen metabolism: Amino acid metabolism
19: Nitrogen metabolism: Nucleotide metabolism
20: Strategies for metabolic control and integration of metabolism: The fed and fasting state and diabetes mellitus
21: Raising electrons of water back up the energy scale: photosynthesis
Part 4: Information storage and utilization
22: The genome
23: DNA synthesis, repair and recombination
24: Gene transcription
25: Protein synthesis and controlled protein breakdown
26: Control of gene expression
27: Protein sorting and delivery
28: Manipulating DNA and genes
Part 5: Cells and Tissues
29: Cell signalling
30: The cell cycle and its control
31: Cell division
32: Cell death: apoptosis
Part 6: Protective mechanisms against disease
34: Blood clotting, xenobiotic metabolism, and reactive oxygen species
35: The immune system
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Dr Despo Papachristodoulou is Senior Lecturer in Biochemistry and also Head of Preclinical Medicine at King's College London School of Medicine. Her research interests include diabetes and diabetic complications, insulin metabolism, intermediary metabolism, nutrition, medical education, and curriculum development.
Dr Alison Snape is Programme Director for the BSc in Biomedical Science and also Lecturer in Biochemistry at King's College London. Her research interests include gene expression and differentiation in early embryonic development. Dr Snape has extensive experience of teaching biochemistry and molecular biology to undergraduates and organises modules for first year students of their BSc Biosciences programmes.