Biochemistry

About this book

For four decades, this extraordinary textbook played a pivotal role in the way biochemistry is taught, offering exceptionally clear writing, and innovative graphics, coverage of the latest research techniques and advances, and a signature emphasis on physiological and medical relevance. Those defining features are at the heart of this new edition.

Paired for the first time with SaplingPlus the most innovative digital solution for biochemistry students. Offering the best combination of resources to help students visualise material and develop successful problem-solving skills in an effort to help students master complex concepts in isolation, and draw on that mastery to make connections across concepts.

Contents

Part I THE MOLECULAR DESIGN OF LIFE
1. Biochemistry: An Evolving Science
2. Protein Composition and Structure
3. Exploring Proteins and Proteomes
4. DNA, RNA, and the Flow of Genetic Information
5. Exploring Genes and Genomes
6. Exploring Evolution and Bioinformatics
7. Hemoglobin: Portrait of a Protein in Action
8. Enzymes: Basic Concepts and Kinetics
9. Catalytic Strategies
10. Regulatory Strategies
11. Carbohydrates
12. Lipids and Cell Membranes
13. Membrane Channels and Pumps
14. Signal-Transduction Pathways

Part II TRANSDUCING AND STORING ENERGY
15. Metabolism: Basic Concepts and Design
16. Glycolysis and Gluconeogenesis
17. The Citric Acid Cycle
18. Oxidative Phosphorylation
19. The Light Reactions of Photosynthesis
20. The Calvin Cycle and the Pentose Phosphate Pathway
21. Glycogen Metabolism
22. Fatty Acid Metabolism
23. Protein Turnover and Amino Acid Catabolism

Part III SYNTHESIZING THE MOLECULES OF LIFE
24. The Biosynthesis of Amino Acids
25. Nucleotide Biosynthesis
26. The Biosynthesis of Membrane Lipids and Steroids
27. The Integration of Metabolism
28. Drug Development
29. DNA Replication, Repair, and Recombination
30. RNA Synthesis and Processing
31. Protein Synthesis
32. The Control of Gene Expression in Prokaryotes
33. The Control of Gene Expression in Eukaryotes

Part IV RESPONDING TO ENVIRONMENTAL CHANGES
34. Sensory Systems
35. The Immune System
36. Molecular Motors

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Biography

Jeremy M. Berg received his B.S. and M.S. degrees in Chemistry from Stanford (where he did research with Keith Hodgson and Lubert Stryer) and his PhD in Chemistry from Harvard with Richard Holm. He then completed a postdoctoral fellowship with Carl Pabo in Biophysics at Johns Hopkins University School of Medicine.

John L. Tymoczko is Towsley Professor of Biology at Carleton College, where he has taught since 1976. He currently teaches Biochemistry, the Metabolic Basis of Human Disease, Oncogenes and the Molecular Biology of Cancer, and Exercise Biochemistry and co-teaches an introductory course, Energy Flow in Biological Systems.

Gregory J. Gatto, Jr., received his A.B. degree in chemistry from Princeton University, where he worked with Martin F. Semmelhack and was awarded the Everett S. Wallis Prize in Organic Chemistry.

Lubert Stryer is Winzer Professor of Cell Biology, Emeritus, in the School of Medicine and Professor of Neurobiology, Emeritus, at Stanford University, where he has been on the faculty since 1976. He received his M.D. from Harvard Medical School.