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About this book
Bioinformatics: Methods Express is unique. It is a book on bioinformatics that makes sense to non-bioinformaticians. It allows researchers who are not bioinformatics specialists to find answers to fundamental bioinformatics questions which they need to pursue their work successfully. It couples accessible theoretical background information with the explicit protocols that non-bioinformaticians need in order to understand what to do - and how to avoid common pitfalls. "Bioinformatics: Methods Express" is a comprehensive but readily-accessible research guide; every chapter discusses the merits and limitations of various bioinformatics approaches and then provides clear advice and unambiguous protocols.
INTRODUCTION Paul H. Dear, MRC Laboratory of Molecular Biology ACCESSING THE AVAILABLE DATA 1. Database resources for wet-bench scientists Neil Hall and Lynn Schriml, TIGR 2. Navigating sequenced genomes Melody Clark and Thomas Schlitt, British Antarctic Survey 3. Sequence similarity searches Jaap Heringa and Walter Pirovano, Vrije Universiteit, Amsterdam IDENTIFICATION AND ANNOTATION OF FEATURES 4. Gene prediction Marie-Adele Rajandream, Wellcome Trust Sanger Institute 5. Prediction of non-coding transcripts Alex Bateman and Sam Griffiths-Jones, Wellcome Trust Sanger Institute 6. Finding regulatory elements in DNA sequence Debraj GuhaThakurta, Merck & Co. and Gary Stormo, Washington University School of Medicine 7. Expressed sequence tags Arthur Gruber, Universidade de Sao Paulo INFERRING PROTEIN STRUCTURE AND FUNCTION 8. Protein structure, classification and prediction Arthur Lesk, Pennsylvania State University 9. Gene ontology Vineet Sangar, Pennsylvania State University 10. Prediction of protein function Rodrigo Lopez, European Bioinformatics Institute COMPARISONS AND PHYLOGENY 11. Multiple sequence alignment Burkhard Morgenstern, University of Gottingen 12. Inferring phylogenetic relationships from sequence data Peter Foster, Natural History Museum Index