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Academic & Professional Books  Environmental & Social Studies  Pollution & Remediation  Toxicology

Chemical Toxicity Prediction Category Formation and Read-Across

By: Mark Cronin(Author), Judith Madden(Author), Steven Enoch(Author), David J Roberts(Author)
288 pages, illustrations
Chemical Toxicity Prediction
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  • Chemical Toxicity Prediction ISBN: 9781849733847 Hardback Sep 2013 Usually dispatched within 1-2 weeks
    £114.99
    #209556
Price: £114.99
About this book Contents Customer reviews Biography Related titles

About this book

The aim of Chemical Toxicity Prediction is to provide the scientific background to using the formation of chemical categories, or groups, of molecules to allow for read-across i.e. the prediction of toxicity from chemical structure. It covers the scientific basis for this approach to toxicity prediction including the methods to group compounds (structural analogues and / or similarity, mechanism of action) and the tools to achieve this. The approaches to perform read-across within a chemical category are also described. Chemical Toxicity Prediction will provide concise practical guidance for those wishing to apply these methods (in risk / hazard assessment) and will be illustrated with case studies.

Chemical Toxicity Prediction is the first book that addresses the concept of category formation and read-across for toxicity prediction specifically. This topic has really taken off in the past few years due to concerns over dealing with the REACH legislation and also due to the availability of the OECD (Q)SAR Toolbox. Much (lengthy and complex) guidance is available on category formation e.g. from the OECD and, to a lesser extent, the European Chemicals Agency but there is no one single source of information that covers all techniques in a concise user-friendly format. There is a real need for this information as in silico toxicology has come to the fore in recent years, primarily as a result of the EU REACH legislation, but also due to many other drivers e.g. reduction of animal testing, Cosmetics regulation. Category formation is seen as the only practical approach to make rational and transparent predictions for complex (human) toxicological endpoints. Chemical Toxicity Prediction covers all the areas required to create a robust category and perform read-across.

Contents

- Preface
- Introduction
- Approaches for Grouping Chemicals and Forming Chemical Categories
- Tools for Grouping Chemicals and Forming Chemical Categories
- Practicalities of Developing Robust Categories and Performing Read-Across
- Case Studies
- Conclusions
- Index

Customer Reviews

Biography

Mark Cronin is a Professor of Predictive Toxicology at Liverpool John Moores University, and has over 20 years of experience in the development of in silico approaches to predict toxicity including the use of QSAR, and read-across. He has published three books and over 160 papers in these areas.

Judith Madden is a reader in Molecular Design at Liverpool John Moores University and has over 15 years experience in the application of QSAR and in silico techniques to predict the ADMET properties of xenobiotics. She has published one book and over 40 papers in these areas.

Steven Enoch is a Post-Doctoral Research Fellow in Predictive Toxicology at Liverpool John Moores University. He is internationally recognised for his research in mechanistic categorisation for toxicology

By: Mark Cronin(Author), Judith Madden(Author), Steven Enoch(Author), David J Roberts(Author)
288 pages, illustrations
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