Two new volumes of Methods in Enzymology continue the legacy of this premier serial with quality chapters authored by leaders in the field. Circadian Rhythms and Biological Clocks, Part A and Part B is an exceptional resource for anybody interested in the general area of circadian rhythms. As key elements of timekeeping are conserved in organisms across the phylogenetic tree, and our understanding of circadian biology has benefited tremendously from work done in many species, Circadian Rhythms and Biological Clocks provides a wide range of assays for different biological systems. Protocols are provided to assess clock function, entrainment of the clock to stimuli such as light and food, and output rhythms of behavior and physiology. Circadian Rhythms and Biological Clocks also delves into the impact of circadian disruption on human health. Contributions are from leaders in the field who have made major discoveries using the methods presented here.
1. Measuring Synchrony in the Mammalian Central Circadian Circuit
Erik D. Herzog, István Z. Kiss and Cristina Mazuski
2. Patch Clamp Electrophysiology in Drosophila Circadian Pacemaker Neurons
Matthieu Flourakis and Ravi Allada
3. Glial Cell Regulation of Rhythmic Behavior
F. Rob Jackson, Fanny S. Ng, Sukanya Sengupta, Samantha You and Yanmei Huang
4. Neurophysiological Analysis of the Suprachiasmatic Nucleus; A Challenge at Multiple Levels
Johanna H. Meijer and Stephan Michel
5. Photic Entrainment in Drosophila Assessed by Locomotor Activity Recordings
Matthias Schlichting and Charlotte Helfrich-Förster
6. Photic Regulation of Clock Systems
Steven Hughes, Aarti Jagannath, Mark W. Hankins, Russell G. Foster and Stuart N. Peirson
7. Response of Peripheral Rhythms to the Timing of Food Intake
Megumi Hatori and Satchidananda Panda
8. Circadian Regulation of Cellular Physiology
Peek, C.B., Ramsey, K.M., Levine, D.C., Marcheva, B., Perelis, M and Bass, J.
9. Analysis of the Redox Oscillations in The Circadian Clockwork
Nikolay B. Milev, Guillaume Rey, Utham K. Valekunja, Rachel S. Edgar, John S. O’Neill and Akhilesh B. Reddy
10. Clocks and Cardiovascular Function
Sarah C. McLoughlin, Philip Haines and Garret A. FitzGerald
11. Measuring Circadian Clock Function in Human Cells
Ludmila Gaspar and Steven A. Brown
12. Human Activity and Rest in Situ
Till Roenneberg, Lena K Keller, Dorothee Fischer, Joana L Matera, Céline Vetter, and Eva C Winnebeck
13. Phenotyping of Neurobehavioral Vulnerability to Circadian Phase During Sleep Loss
Namni Goel, Mathias Basner and David F. Dinges
14. Genetics of Human Sleep Behavioral Phenotypes
Pei-Ken Hsu, Louis J. Ptácek and Ying-Hui Fu
15. Sleep and Circadian Rhythm Disruption and Recognition Memory in Schizophrenia
Shu K. E. Tam, David Pritchett, Laurence A. Brown, Russell G. Foster, David M. Bannerman and Stuart N. Peirson
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Dr. Sehgal is the John Herr Musser Professor of Neuroscience and Director of a Program in Chronobiology at the Perelman School of Medicine, University of Pennsylvania. She has also been an Investigator of the Howard Hughes Medical Institute since 1997. Dr. Sehgal received her Ph.D. from the Graduate School of Medical Sciences, Cornell University, working with Dr. Moses Chao, and conducted her postdoctoral work with Dr. Michael Young at Rockefeller University. A major focus in her laboratory is the cellular and molecular basis of circadian rhythms, using the fruit fly, Drosophila melanogaster as a model system. Her laboratory also developed a Drosophila model for the study of sleep, which has been adopted by laboratories worldwide, and is rapidly provding insight into the regulation and function of sleep. In 2009, Dr. Sehgal was elected to the Institute of Medicine and in 2011 to the American Academy of Arts and Sciences.