About this book
Molecular tools and biochemical processes are now central to much of our understanding of the biological and biomedical sciences - from the study of ecological interactions and animal behaviour to the causes and treatment of disease. Biochemistry and Molecular Biology is the perfect resource for any student who needs to know the principles of this fascinating subject - whether they are studying biology or biochemistry, biomedical science or nutrition.
The book blends the fundamentals of cell biology and biochemistry with the latest advances in genomics and proteomics to give a contemporary, accurate depiction of the field, while always maintaining a wonderful clarity, enriched by carefully layered explanations and vivid illustrations. It is the ideal companion as you explore biochemistry and molecular biology for the first time.
Contents
Part 1 Basic concepts of life
1. The basic molecular themes of life
2. Cells and viruses
3. Energy considerations in biochemistry
Part 2 Structure and function of proteins and membranes
4. The structure of proteins
5. Methods in protein investigation
6. Enzymes
7. The cell membrane and membrane proteins
8. Muscle contraction, the cytoskeleton, and molecular motors
Part 3 Metabolism
9. Food digestion, absorption, distribution to the tissues and appetite control
10. Mechanisms of transport, storage and mobilisation of dietary components
11. Principles of energy release from food
12. Glycolysis, the citric acid cycle, and the electron transport system
13. Energy release from fat
14. The synthesis of fat and related compounds
15. Synthesis of glucose (gluconeogenesis)
16. Strategies for metabolic control and their applications to carbohydrate and fat metabolism
17. Why should there be an alternative pathway of glucose oxidation? The pentose phosphate pathway
18. Raising electrons of water back up the energy scale - photosynthesis
19. Amino acid metabolism
20. Nucleotide synthesis and metabolism
Part 4 Information storage and utilisation
21. Genome
22. DNA synthesis, repair and recombination
23. Gene transcription and control
24. Protein synthesis and controlled protein breakdown
25. The RNA world - RNA microgenes and RNA interference
26. Protein sorting and delivery
27. Cell signalling
28. Manipulating DNA and genes
Part 5 Molecular biology in health and disease
29. Special topics: blood clotting, xenobiotic metabolism, oxygen free radicals
30. The immune system
31. The cell cycle and its control
32. Apoptosis
33. Cancer
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