About this book
Centrosomes play an integral role in the growth of cells and the ultimate development of many animals, and sometimes plants. In addition to the normal growth of cells, centrosomes can also play a key role in the spread of cancer and are of increased interest to both the genetics and oncology communities. Volume 49 of "Current Topics in Developmental Biology" will present all known research surrounding the centrosome, across a variety of systems, will be well referenced, and speculate where the research is headed. It discusses centrosomes and cancer, centrosomes and early development, and molecular biology of the centrosome. It is heavily illustrated, with many color figures. Chapters are written by international leaders in the field.
Contents
The Centrosome and Parthenogenesis, T. Kuntziger and M. Bornens. g -Tubulin, B.R. Oakley. g -Tubulin Complexes and Their Role in Microtubule Nucleation, R.N. Gunawardane, S.B. Lizarraga, C. Wiese, A. Wilde, and Y. Zheng. g -Tubulin of Budding Yeast, J. vogel and M. Snyder. The Spindle Pole Body of Saccharomyces cerevisiae: Architecture and Assembly of the Core Components, S.E. Francis and T.N. Davis. The Microtubule Organizing Centers of Schizosaccaromyces pombe, I.M. Hagan and J. Petersen. Comparative Structural, Molecular, and Functional Aspects of the Dictyostelium discoideum Centrosome, R. Graf, N. Brusis, C. Daunderer, U. Euteneur, A. Hestermann, M. Schliwa, and M. Ueda. Are There Nucleic Acids in the Centrosome?, W.F. Marshall and J.L. Rosenbaum. Basal Bodies and Centrioles: Their Function and Structure, A.M. Preble, T.M. Giddings, Jr., and S.K. Dutcher. Centriole Duplication and Maturation in Animal Cells, B.M.H. Lange, A.J. Faragher, P. March, and K. Gull. Centrosome Replication in Somatic Cells: The Significance of the G1 Phase, R. Balczon. The Coordination of Centrosome Reproduction with Nuclear Events during the Cell Cycle, G. Sluder and E.H. Hinchcliffe. Regulating Centrosomes by Protein Phosphorylation, A.M. Fry, T. Mayor, and E.A. Nigg. The Role of the Centrosome in the Development of Malignant Tumors, W.L. Lingle and J.L. Salisbury. The Centrosome-Associated Autora/lpl-like Kinase Family, T.M. Goepfert and B.R. Brinkley. Centrosome Reduction during Mammalian Speriogenesis, G. Manandhar, C. Simerly, and G. Schatten. The Centrosome of the Early C. elegans Embryo: Inheritance, Assembly, Replication, and Developmental Roles, K.F. O'Connell. The Centrosome in Drosophila Oocyte Development, T.L. Megraw and T.C. Kaufman. The Centrosome in Early Drosophila Embryogenesis, W.F. Rothwell and W. Sullivan. Centrosome Maturation, R.E. Palazzo, J.M. Vogel, B.J. Schnackenberg, D.R. Hull, and X. Wu. Index. Contents of Previous Volumes.
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