Integrated assessments of the impacts of, and adaptation to, climate change and variability at urban and regional scales are presented in this comprehensive volume. Six thematically distinct yet methodologically related projects illustrate `horizontal' integration, which focuses on impacts and responses across different sectors, and `vertical' integration, which traces changes from the climate system through to the economy and society. Areas of application include water resource allocation, wildfire management, agriculture, public health and urban infrastructure in the United States.