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DNA-Protein: Structural Interactions

Series: Frontiers in Molecular Biology Volume: 7

Edited By: David M J Lilley

216 pages, 7 b/w photos, 50 illus

IRL Press

Paperback | Dec 1995 | #48501 | ISBN: 019963453X
Availability: Usually dispatched within 2-3 weeks Details
NHBS Price: £69.99 $92/€78 approx
Hardback | Dec 1995 | #48502 | ISBN: 0199634548
Out of Print Details

About this book

Many processes in the genetic life of the cell require a specific interaction between proteins and DNA. While DNA is normally thought of as a straight double helix, it can be distorted by bending and twisting, and these alterations are critical to a number of cellular processes. These include transcription (by which the genetic message is read), recombination (rearrangements by which new combinations of genes come about), and the repair of DNA damage. An interesting group of proteins have the important role of recognizing and manipulating DNA structure. This text explores the importance of DNA structure in the interactions between proteins and DNA in order to generate a new perspective on DNA-protein.

[T]he reader is left with a deep appreciation for the structural and mechanistic possibilities that have emerged from the long co-evolution of DNA and DNA-binding proteins.--Quarterly Review of Biology


1. DNA-protein interaction at high resolution; 2. DNA bending by sequence and proteins; 3. Enzymes that supercoil DNA; 4. Recognition of DNA damage and repair; 5. Structure-recognition by DNA junction resolving enzymes; 6. Site-specific recombinases and their interactions with DNA; 7. The HMG-box domain

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