Retroviruses

About this book

Since the mid-1970s, the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biomechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphona have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This volume aims to satisfy that need.

Contents

Historical introduction to the general properties of retroviruses; retroviral virions and genomes; viral entry and receptors; reverse transcriptase and the generation of retroviral DNA; integration; synthesis and processing of viral RNA; synthesis, assembly and processing of viral proteins; the interactions of retroviruses and their hosts; retrotransposons, endogenous retroviruses and the evolution of retroelements; development and applications of retroviral vectors; retroviral pathogenesis; pathogenesis of HIV and SIV; immunological and pharmacological approaches to the control of retroviral infections. Appendices: retroviral sequences; retroviral taxonomy, protein structures, sequences and genetic maps.

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