This 2-volume work contains a collection of essential articles covering key topics in Epigenetics. The first volumed covers the fundamentals of Epigenetics starting from molecular and cellular processes and the epigenenome. The second volume focuses on epigenetics of various organisms ranging from plants to humans and describes current and emerging technologies as well as medical applications. Among the chapters are updated articles from the acclaimed "Meyers Encyclopedia of Molecular Cell Biology and Molecular Medicine". The book gives a comprehensive overview of Epigenetic mechanisms in the cell, and provides an overview of analytical aspects and medical applications.
Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused attention on these genome modifications. The molecular basis of epigenetics involves modifications to DNA and the chromatin proteins that associate with it. Methylation, for example, can silence a nearby gene and seems to be involved in some cancers.
Epigenetics is beginning to form and take shape as a new scientific discipline, which will have a major impact on Medicine and essentially all fields of biology. Increasingly, researchers are unearthing links between epigenetics and a number of diseases. Although in recent years cancer has been the main focus of epigenetics, recent data suggests that epigenetic plays a critical role in psychology and psychopathology. It is being realized that normal behaviors such as maternal care and pathologies such as Schizophrenia and Alzheimer's might have an epigenetic basis. It is also becoming clear that nutrition and life experiences have epigenetic consequences.
- Histone Modifications
- Chromatin Dynamics and Higher Order Chromatin Organization
- Heterochromatin and Euchromatin-Organization, Boundaries, and Gene Regulation
- Regulation of Gene Expression
- Regulation of Gene Expression at the Beginning of Mammalian Development
- Monozygotic Twins and Epigenetics
- Chromosome Territory Organization within the Nucleus
- The Cell Nucleus: Biogenesis, Structure, and Function
- Molecular Genetics of Genomic Imprinting
- Imprinting and the Epigenetic Asymmetry between Parental Genomes
- The Human Epigenome
- Parental Genomic Imprinting in Flowering Plants
- Prions as Epigenetic Regulators of Phenotype in Fungi
- RNA Methodologies
- DNA Methylation Analysis by MALDI Mass Spectrometry
- All Things ChIP: ChIP-chip, ChIP-Seq, ChIP-PCR
- Computational Epigenetics
- Epigenetic Medicine
- Epigenetic Regulation in Pluripotent Stem Cells
- Epigenetics of the Immune System
- Pharmaco-epigenomics to Improve Cancer Therapies
- Epigenetics of Ciliates
- Nuclear Transfer for Cloning Animals
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Robert A. Meyers obtained his Ph.D. in Chemistry at the University of California at Los Angeles. He was a post-doctoral fellow at the California Institute of Technology and has more than 17 patents, 50 technical papers and 12 books to his name. As Editor-in-Chief he conceived and edited several ambitious multivolume reference works, e.g. the "Encyclopedia of Analytical Chemistry" (Wiley), the :Encyclopedia of Molecular Biology and Molecular Medicine" (Wiley-VCH) and the "Encyclopedia of Physical Science and Technology" (Academic Press).