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Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence. This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility. The other one deals with parental genomic imprinting, a process which allows to express a few selected genes from only one of the parental allele while extinguishing the other.
Chromatin Remodelling Factors and DNA Replication.- Epigenetic Inheritance of Chromatin States Mediated by Polycomb- and Trithorax Group Proteins in Drosophila.- How to Pack the Genome for a Safe Trip.- Chromatin Modifications on the Inactive X Chromosome.- Chromatin Mechanisms in Drosophila Dosage Compensation.- DNA Methylation in Epigenetic Control of Gene Expression.- The Epigenetic Breakdown of Cancer Cells: From DNA Methylation to Histone Modifications.- Developmental Regulation of the beta-globin Gene Cluster in Mouse.- Epigenetic Regulation of Mammalian Imprinted Genes : from Primary to Functional Imprints.- Seed Development and Genomic Imprinting in Plants.
From the reviews: "This book contains ten excellent chapters ! . Thoroughly covers a rapidly developing and expanding field. The different chapters are well written and provide clear, concise and informative views on the topic. Notably, each chapter ends with a conclusion describing current models and future challenges in epigenetics. ! both the expert and the novice will find this book a valuable source of information on the various epigenetic phenomena." (Frank Sauer, Nature Cell Biology, Vol. 7 (10), October, 2005) "Professor Philippe Jeanteur, who is one of the editors of this PMSB Springer series, coordinated a well reknown group of scientists working on epigenetics to provide us with an updated collection of papers treating epigenetic phenomena in Mammals, insects and plants. Well done: careful presentations, well illustrated and rich in bibliography, this book is a must for those interested in epigenetics." (Carlo Alberto Redi, European Journal of Histochemistry, Vol. 49 (4), 2005)