984 pages, colour photos, colour illustrations, tables
An understanding of epigenetics is central to research in transcriptional regulation, development, and disease. The second edition of the best-selling Epigenetics textbook builds on the strong foundation of the first edition, expanding from 24 to 36 expertly written chapters. Revised chapters from the first edition cover the basic molecular mechanisms underpinning epigenetic regulation, discussing many cellular processes that rely on this kind of regulation, and survey the studies carried out in the whole spectrum of model organisms in which it has been most studied.
New to Epigenetics is the inclusion of the expanding structural data on the machinery that modifies histones and DNA, giving weight and understanding to the molecular workings of chromatin and epigenetics. Also new is the inclusion of studies showing how chromatin remodeling machinery, and the higher order 3-D organization of the nucleus, are contributing to epigenetic regulation. A chapter is dedicated to the mounting evidence in mouse models of transgenerational epigenetic inheritance. Findings from studies of development, reprogramming, and disease highlight not only the importance of epigenetics but also the potential for epigenetic therapy, as illustrated in chapters covering the immune and neuronal systems, and cancer.
Epigenetics is a major resource for those working in the field, as well as a suitable text for advanced undergraduate and graduate courses on gene regulation.
There are currently no reviews for this book. Be the first to review this book!
Edited by C. David Allis, The Rockefeller University; Marie-Laure Caparros, London; Thomas Jenuwein, Max-Planck Institute of Immunobiology and Epigenetics; Danny Reinberg, Howard Hughes Medical Institute, New York University School of Medicine-Smilow Research Center; Associate Editor Monika Lachner, Max-Planck Institute of Immunobiology and Epigenetic