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By: C David Allis(Editor), Marie-Laure Caparros(Editor), Thomas Jenuwein(Editor), Danny Reinberg(Editor), Monika Lachner(Editor)

984 pages, colour photos, colour illustrations, tables

Cold Spring Harbor Laboratory Press

Hardback | Apr 2015 | Edition: 2 | #212338 | ISBN-13: 9781936113590
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About this book

An understanding of epigenetics is central to research in transcriptional regulation, development, and disease. The second edition of the best-selling Epigenetics textbook builds on the strong foundation of the first edition, expanding from 24 to 36 expertly written chapters. Revised chapters from the first edition cover the basic molecular mechanisms underpinning epigenetic regulation, discussing many cellular processes that rely on this kind of regulation, and survey the studies carried out in the whole spectrum of model organisms in which it has been most studied.

New to Epigenetics is the inclusion of the expanding structural data on the machinery that modifies histones and DNA, giving weight and understanding to the molecular workings of chromatin and epigenetics. Also new is the inclusion of studies showing how chromatin remodeling machinery, and the higher order 3-D organization of the nucleus, are contributing to epigenetic regulation. A chapter is dedicated to the mounting evidence in mouse models of transgenerational epigenetic inheritance. Findings from studies of development, reprogramming, and disease highlight not only the importance of epigenetics but also the potential for epigenetic therapy, as illustrated in chapters covering the immune and neuronal systems, and cancer.

Epigenetics is a major resource for those working in the field, as well as a suitable text for advanced undergraduate and graduate courses on gene regulation.

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1. A Brief History of Epigenetics
Gary Felsenfeld
2. Outlook: Looking into Epigenetics
i) The Discovery of Histone Demethylases
Y.G. Shi and Y. Tsukada
ii) Cellular Reprogramming
K. Takahashi
iii) IncRNAs: Linking RNA to Chromatin
J.L. Rinn
iv) Enhancer RNAs: A Class of Long Noncoding RNAs Synthesized at Enhancers
Tae-Kyung Kim, Martin Hemberg, and Jesse M. Gray
v) Novel Modifications of Cytosine in Genomic DNA
S. Kriaucionis and M. Tahiliani
vi) Plant Mobile Small RNAs
P. Dunoyer, C.W. Melnyk, A. Molnar, and R.K. Slotkin
vii) CpG island Chromatin is Shaped by Recruitment of ZF-CxxC Proteins
N. Blackledge, J. Thomson, and P. Skene
viii) A Bromodomain and Extraterminal Domain Inhibitor (BETi) for Cancer Therapy
J. Qi
ix) BET Inhibitors II
U. Schaefer
x) Histone H3 Mutations in Pediatric Brain Tumors
X. Liu, T. McEachron, J. Schwartzentruber, and G. Wu
xi) Chromosome Folding: Driver or Passenger of Epigenetic State
T. Sexton and E. Yaffe
3. Overview and Concepts
C. David Allis, Thomas Jenuwein, Danny Reinberg
4. Writers and Readers of Histone Acetylation: Structure, Mechanism and Inhibition
Ronen Marmorstein and Ming-Ming Zhou
5. Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
Edward Seto and Minoru Yoshida
6. Structural and Functional Coordination of DNA and Histone Methylation
Ziaodong Cheng
7. A Structural Perspective on Readout of Epigenetic H & DM Marks
D. Patel
8. Epigenetics in Saccharomyces cerevisiae
Michael Grunstein and Susan M. Gasser
9. Epigenetics in Saccharomyces pombe
R. Allshire and K. Ekwall
10. Neurospora crassa, a Model System for Epigenetics Research
Rodolfo Aramayo and Eric U. Selker
11. Epigenetics of Ciliates
Douglas L. Chalker, Eric Meyer, and Kazufumi Mochizuki
12. Position Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila
Sarah C.R. Elgin and Gunter Reuter
13. Epigenetic Regulation in Plants
C. Pikaard and O. Mittelsten Scheid
14. The Use of Mouse Models to Study Epigenetics
Marnie Blewitt and Emma Whitelaw
15. DNA Methylation in Mammals
En Li and Yi Zhang
16. RNAi and Primal RNAs
R. Martienssen and D. Moazed
17. Transcriptional Silencing by Polycomb Group Proteins
U. Grossniklaus and R. Paro
18. Transcriptional Regulation by Trithorax Group Proteins
R. Kingston and J. Tamkun
19. Long-range Chromatin Interactions
J. Dekker and T. Misteli
20. Histone Variants and Epigenetic Inheritance
S. Henikoff and M. Smith
21. Nucleosome Remodeling and Epigenetics
P.B. Becker and J.L. Workman
22. Maintenance of Epigenetic Information
G. Almouzni and H. Cedar
23. Regulation of the X Chromosomes in C. elegans
Susan Strome, William G. Kelly, Sevinc Ercan, and Jason D. Lieb
24. Dosage Compensation in Drosophila
M. Kuroda and J. Lucchesi
25. Dosage Compensation in Mammals
N. Brockdorff and B. Turner
26. Genomic Imprinting in Mammals
Denise P. Barlow and Marisa S. Bartolomei
27. Germ Line and Pluripotent Stem Cells
A Surani and W. Reik
28. Induced Pluripotency and Epigenetic Reprogramming
K. Hochedlinger and R. Jaenisch
29. Epigenetic Control of Immunity
M. Busslinger and A. Tarakhovsky
30. Metabolic Signalling to Chromatin
S. Berger and P. Sassone-Corsi
31. Epigenetic Regulation in Plant Responses to the Environment
D. Baulcombe and C. Dean
32. Epigenetic Regulation in Neuronal Development
S. Lomvardas and T. Maniatis
33. Epigenetics and Human Disease
A. Beaudet and H. Zoghbi
34. Epigenetic Determinants of Cancer
P. Jones and S. Baylin
35. Epigenetics and Cancer II
J. Audia and R. Campbell
36. Perspectives on Epigenetics
V. Pirrotta

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Edited by C. David AllisThe Rockefeller University; Marie-Laure CaparrosLondon; Thomas JenuweinMax-Planck Institute of Immunobiology and Epigenetics; Danny ReinbergHoward Hughes Medical Institute, New York University School of Medicine-Smilow Research Center; Associate Editor Monika LachnerMax-Planck Institute of Immunobiology and Epigenetic

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