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Provides a clear analysis of the importance of non-additivity to the evolutionary process, consolidating the empirical and conceptual findings from epistasis research.
Introductions and Concepts; 1. Why evolutionary genetics doesn't always add up; 2. Beyond the average: The evolutionary importance of gene interactions and variability of epistatic effects; 3. Epistasis and Complex Traits; 4. Detecting epistasis among quantitative trait loci; 5. The evolution of developmental interations: Epistasis, canalization, and integration; 6. Epistasis and the maintenance of sex; 7. Genetic partners in crime: Evolution of an ultraselfish supergene that specializes in sperm sabotage; 8. Modeling gene interaction in structured populations; 9. Epistasis, linkage, and balancing selection; 10. Indirect genetic effects and gene interactions; 11. Epistasis in morphology and mating behavior; Genetic Differentiation: From Populations to Speciation; 12. Gene interactions and the origin of species; 13. Epistasis as a genetic constraint within populations and an accelerant of adaptive divergence among them; 14. The contribution of epistasis to the evolution of natural populations: A case study of an annual plant; 15. Epistasis and the evolution of genetic architectures in natural populations; 16. Inferring Epistasis in wild sunflower hybrid zones; Literature cited; Index