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From Enzyme Models to Model Enzymes

By: Anthony J Kirby and Florian Hollfelder

286 pages, illus, tabs

Royal Society of Chemistry

Hardback | Oct 2009 | #183110 | ISBN-13: 9780854041756
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NHBS Price: £132.99 $173/€151 approx

About this book

Designing artificial systems with catalytic efficiencies to rival those of natural enzymes is one of the great challenges facing science today. This book provides a critical introduction to, and overview of, this exciting area.

Enzymes and how they work is a fascinating topic not only for chemists and biochemists, but for scientists in general, and the current importance of green" and sustainable chemistry has not made the topic any less interesting." " excellent text for those who wish to enter or work in the field of enzyme mimicry." "Anthony Kirby is a first-rate expert in the area and, together with his younger colleagues, leads one through it with care and thoroughness." -- ChemBioChem, 2010, 11, 581 - 583 ChemBioChem "The organizational is logical, progressing from an introduction of the principles of catalysis through model systems to more sophisticated efforts that include biochemical methods to improve the catalytic function of proteins." "The coverage of topics is broad rather than deep, consistent with the authors' goal of introducing enzyme models to a wide readership." "Overall this is a valuable mongraph, particularly for those who are reasonably conversant with the underlying principles of catalysis. The text is very well written and the coverage of the topic is sufficient to give a broad overview of the field." -- JACS, 2010, 132, 3637-3638 Journal of the American Chemical Society (JACS)


Introduction Evaluation Classification by model system Classification by reaction Problems Glossary Index

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Anthony J. Kirby is Professor (Emeritus) of Bioorganic Chemistry at the University of Cambridge. He has over 40 years teaching and research experience in the area and has authored over 300 papers and 3 books. Florian Hollfelder has been lecturing in Biochemistry since 2001. He has a total of 15 years teaching and research experience at Cambridge, Stanford & Harvard and has authored more than 30 papers.

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