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Academic & Professional Books  Evolutionary Biology  Evolution

Gene Sharing and Evolution The Diversity of Protein Functions

By: Joram Piatigorsky
320 pages, 30 colour illustrations, 11 line illustrations
Gene Sharing and Evolution
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  • Gene Sharing and Evolution ISBN: 9780674023413 Hardback Mar 2007 Not in stock: Usually dispatched within 6 days
    £80.95
    #160707
Price: £80.95
About this book Contents Customer reviews Biography Related titles

About this book

Gene sharing means that the different functions of a protein may share the same gene--that is, a protein produced by a gene evolved to fulfill a specialized function for one biological role may also perform alternate functions for other biological roles.

In the 1980s and early 1990s, Joram Piatigorsky and colleagues coined the term "gene sharing" to describe the use of multifunctional proteins as crystallins in the eye lens. In Gene Sharing and Evolution Piatigorsky explores the generality and implications of gene sharing throughout evolution and argues that most if not all proteins perform a variety of functions in the same and in different species, and that this is a fundamental necessity for evolution.

How is a gene identified, by its structure or its function? Do the boundaries of a gene include its regulatory elements? What is the influence of gene expression on natural selection of protein functions, and how is variation in gene expression selected in evolution? These are neither new nor resolved questions. Piatigorsky shows us that the extensiveness of gene sharing and protein multifunctionality offers a way of responding to these questions that sheds light on the complex interrelationships among genes, proteins, and evolution.

Contents

List of Illustrations Preface 1. What Is "Gene Sharing"? New Functions for Old Proteins and the Question of Gene Duplication Origin of the Term "Gene Sharing" Gene Sharing: General Definition and Implications Protein Location and Gene Regulation Why the Term "Gene Sharing"? Mechanisms for Diversifying Gene Functions Posttranslational Modifications Conditions for Initiating Gene Sharing Contrasting Phenotype with Protein Function Take-Home Message 2. Multifunctions and Functional Shifts: Echos from the Past Preadaptation, Prospective Adaptation, and Hopeful Monsters Quirky Functional Shifts and Exaptation Spandrels and Gene Sharing Gene Regulation and Tinkering Take-Home Message 3. The Elusive Concept of a "Gene" The Classical Gene Concept The Mendel-Morgan Chromosomal Theory of the Gene Later Developments: One Gene/One Enzyme/One Polypeptide The Molecular Era of the Gene: So Much Data, So Many Possibilities Quantifying Genes before the Molecular Era Quantifying Genes in the Molecular Era: Fewer than Expected Noncoding Regulatory Genes Protein Diversity The Ambiguous Gene The "Molecular Gene" Concept The "Molecular Process Gene" Concept The "Evolutionary Gene" Concept Two Concepts for One Gene: Gene-P/Gene-D Gene Sharing: A Concept Incorporating an "Open Gene" Take-Home Message 4. Eyes and Lenses: Gene Sharing by Crystallins Eye Diversity: Many Forms to Perform a Function The Lens Crystallins and the Optical Properties of the Lens Diversity and Taxon-Specificity of Lens Crystallins Crystallins Are Borrowed Proteins The bg-Crystallins: A Superfamily with Distant Stress Connections The Enzyme-Crystallins of Vertebrates Crystallins of Invertebrates Crystallin Gene Regulation in Vertebrates: A Similar Cast of Transcription Factors Convergent Evolution of Crystallin Gene Expression Evolutionary Dynamism of shsp/aB-Crystallin Gene Expression Convergent Evolution of Invertebrate and Vertebrate Crystallin Promoters Potential for Lens-Specific Promoter Activity Convergent Evolution and Relaxed Stringency for Crystallins Take-Home Message 5. The Enigmatic "Corneal Crystallins": Putative Cases of Gene Sharing The Cornea Aldehyde Dehydrogenase: A Candidate Corneal Crystallin Other Candidate Corneal Crystallins: Transketolase, Isocitrate Dehydrogenase, and Cyclophilin Adseverin: A Corneal Crystallin in Zebrafish A Signaling Role for Adseverin Corneal Gene Expression The Refracton Hypothesis: Implications for Gene Sharing Take-Home Message 6. Gene Sharing As a Common Event: Many Multifunctional Proteins Glycolytic Enzymes and the Versatile Hexokinases Citrate Synthase: An Enzyme and a Cytoskeletal Structure Lactate Dehydrogenase: An Enzyme for All Seasons Regulation of mRNA Translation by Enzyme Binding Glyceraldehye-3-phosphate Dehydrogenase: Constant Surprises Enolase: Another Versatile Protein Bacterial Surface Enzymes Xanthine Oxidoreductase: Enzyme and Envelope The Thioredoxin/Ribonucleotide Reductase System and Thioredoxin Family Members: From Redox to Morphogenesis Serum Albumin: Transport Protein, Enzymatic Vasodilator and Detoxifier Gelsolin: Roles in Cytoskeletal Structure, Gene Expression, Cell Death, and Signal Transduction Cytochrome c: Roles in Electron Transport, Cell Death, and Light Filtration Take-Home Message 7. Gene Sharing during Gene Expression Complexity of Transcription Nuclear Receptors Metabolic Enzymes and Gene Expression Y-Box Proteins Transcription Factors as Translational Regulators: Bicoid Translation Factors for RNA Export: eIF4 Homeoproteins, Chromosomal Proteins and Actin The Dynamic Flux of Nuclear Proteins Take-Home Message 8. Gene Sharing As a Dynamic Evolutionary Process: Antifreeze Proteins and Hemoglobins Antifreeze Proteins Hemoglobins Take-Home Message 9. Gene Duplication and the Evolution of New Functions Gene Duplication and Retention of Redundant Genes Birth and Death of Duplicated Genes Adaptive Evolution by Positive Selection: New Functions after Gene Duplication Subfunctionalization and Gene Sharing Rapid Subfunctionalization with Slow Neofunctionalization Gene Sharing Is Independent of Gene Duplication Lens Crystallins: Gene Sharing at Different Stages of Duplication Take-Home Message 10. Gene Sharing and Systems Biology: Implications and Speculations Networks Evolvability Selective Pressure Affecting Gene Regulation Functional Switching and the Notion of Functional "Trespassing" Functional Noise Genetic Differences in Levels of Gene Expression The Molecular Clock Gene Knockout Experiments Gene Deletion of b-Catenin Horizontal Gene Transfer Take-Home Message 11. Recapitulations: Ambiguities and Possibilities Ambiguity of Cause and Effect Natural Selection Versus Random Drift Gene Sharing and Robustness: When Is a Mutation Neutral? Inconsistency with Design Naming Is Not Knowing The Question of Tissue Homology Phylogenetic Trees: The Complication of Function Defining and Counting Genes Definition of Polypeptide Function: The Ambiguity of Molecular Mechanism Between Genotype and Phenotype Gene Sharing and the Importance of Research on Diverse Species Medical Implications Glossary References Index

Customer Reviews

Biography

Joram Piatigorsky is Chief of the Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health.
By: Joram Piatigorsky
320 pages, 30 colour illustrations, 11 line illustrations
Media reviews
[Gene Sharing and Evolution] provides great motivation for evolutionists to continue investigating the origins of new protein function, a topic central to evo-devo biology. The book is a parade of interesting molecular biology with abundant and clear color illustrations. The work is copiously referenced. With over 1100 references in the bibliography, most anyone is certain to find new and interesting literature. As such, I recommend Gene Sharing and Evolution for a graduate seminar, as a reference book on gene multi-functionality with many detailed examples, and for anyone pondering the evolutionary origins of novelty at the molecular level. -- Todd H. Oakley Evolution & Development A masterpiece for a broad medical and scientific readership. The text provides a powerful reminder that genes and proteins do not function as isolated entities but are components of a dynamic and elaborate temporal network. With the recent advent of the -omics disciplines, we are witnessing fundamental changes that propel biomedical sciences toward a new level, in which the global perspectives become the fundamental priority. -- Richard A. Stein Journal of the American Medical Association 20070919
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