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By: Michael Lynch and Bruce Walsh
980 pages, Figs, tabs
Brings together the diverse array of theoretical and empirical applications of quantitative genetics under one cover, in a way that is both comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics.
`...An outstanding achievement. It gives a comprehensive coverage of the principles of the inheritance of continuous traits and of the ways to analyze them, covering both classical and modern methods with clarity and depth. The book will be of value to students and researchers in areas ranging from population and evolutionary biology to human disease and animal breeding. I am certain it will become a standard reference for years to come' William G Hill.
I. The Genetic Basis of Quantitative Variation - An Overview of Quantitative Genetics - Properties of Distributions - Covariance, Regression, and Correlation - Properties of Single Loci - Sources of Genetic Variation for Multilocus Traits - Sources of Environmental Variation - Resemblance Between Relatives - Introduction to Matrix Algebra and Linear Models - Analysis of Line Crosses - Inbreeding Depression - Matters of Scale - II. Quantitative-Trait Loci - Polygenes and Polygenic Mutation - Detecting Major Genes - Basic Concepts of Marker-Based Analysis - Mapping and Characterizing QTLs: Inbred-Line Crosses - Mapping and Characterizing QTLs: Outbred Populations - III. Estimation Procedures - Parent-Offspring Regression - Sib AnalysisTwins and Clones - Cross-Classified Designs - Correlations Between Characters - Genotype x Environment Interaction - Maternal Effects Sex Linkage and Sexual Dimorphism - Threshold Characters - Estimation of Breeding Values - Variance-Component Estimation with Complex Pedigrees - Appendices - Expectations, Variances and Covariances of Compound Variables - Path Analysis - Matrix Algebra and Linear Models - Maximum Likelihood Estimation and Likelihood-Ratio Tests - Estimation of Power of Statistical Tests -
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