Genome Science is a textbook and laboratory manual for advanced, secondary, and post-secondary education. It combines approachable narrative with extensively tested lab exercises that integrate key concepts of genome biology in humans, plants, and invertebrates. Each stand-alone lab merges bioinformatics methods with molecular technologies. The labs are organized into units, each with an introduction providing an historical and conceptual framework. This modular structure provides many options for integrating the material into existing courses, starting new courses, or supporting student research projects.