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About this book
About this book
Since the first edition of Guidebook to Cytoskeletal and Motor Proteins many new and important discoveries have been made on the structure and function of proteins involved in the microfilament, microtubule and intermediate filament systems in cells. Even specialists in the field have found it difficult to keep up with the information that has emerged in recent years on this diverse range of eukaryotic proteins, their genes, and the roles that they play in cell structure, motor function and signalling. The Sambrook & Tooze guidebooks provide succinct and up-to-date information on particular classes of important biological molecules, accompanied by short bibliographies, which enable both specialists and newcomers to the field to gain access to unfamiliar work. This volume begins with a comprehensive catalogue of the structure and function of cytoskeletal actin, tubulin, and intermediate filaments and their associated proteins There is further coverage of proteins which are involved in 'New Filament Systems'. A section on 'Molecular Motors and Associated Proteins' details all that is currently known about the major motor protein families and the proteins which are associated with them in the motor complex. In addition, a section on 'Organelle Structural Proteins' describes the roles these proteins have in efficient intracellular communication and function.
List of contributors; List of plates; Part 1. Actin and associated proteins; Introduction; Actin; Actin-binding protein 120 (ABP-120); Actin depolymerizing factor (ADF)/cofilin; *a-Actinins; Actobindin; Actolinkin; Adducin; Angiogenin; Anillin; Annexins; Arp1 (centractin); Arp2/3 complex; Arps, divergent members; Caldesmon; Calponin; Cap 110/protovillin; Capping protein; *a-Catenin; Coronin; Cortexillins; Dematin; Drebrin; Drosophila actin-associated proteins: Bottleneck, Nullo, and Serendipity-*a; Dystrophin/utrophin; Elongation factor 1A (eEF1A); Fascin; Filamin; Fimbrin; Gelsolin; Hisactophilin; MARCKS family; Nebulin; p58gag; Ponticulin; Profilins; Protein 4.1; Scruin; Severin; Sla1p; Sla2p; Small actin cross-linking proteins; Smoothelin; Spectrins; Talin; Tensin; Tenuin; Thymosin *b4; Transgelin; Tropomodulin; Tropomyosins; Troponin; VASP; Vinculin; Villin; Vitamin D-binding/Gc protein; Wiskott-Aldrich syndrome protein (WASP); 25kDa inhibitor of actin polymerization (25 kDa IAP); Part 2. Tubulin and associated proteins; Introduction; 2a. Tubulin and MAPs; APC protein; CLIP-170; Drosophila 205K MAP; E-MAP-115; MAP1A; MAP1B/MAPS; MAP2; MAP4; Mapmodulin; MARK protein kinases; MARPs; Op18/stathmin; Radial spoke proteins; STOPS; Syncolin; Tau protein; Tea1; Tektins; *a/*b-Tubulins; Tubulin-specific chaperones; Tubulin tyrosine ligase and tubulin carboxypeptidase; XMAP215; XMAP230; XMAP310; 2b. Centrosomal proteins; Centrosomin; CP190/CP60; Katanin; NuMa; Perecentrin; *g-Tubulin; Yeast spindle pole body proteins; Part 3. Intermediate filaments and associated proteins; Introduction; Structural features of IF proteins; Evolutionary aspects of IF proteins; 3a. Intermediate filaments; Cytokeratins; Desmin; GFAP; *a-Internexin; Lens beaded filament proteins; Nestin; Neurofilament triplet proteins; Nuclear lamins; Peripherin; Synemin; Vimentin; 3b. Intermediate filament associated proteins; BPAG1; Filaggrins; IFAP 300; Lamin-associated proteins; Part 4. New filament systems; Introduction; Plectin; Centrin; FtsZ; Major sperm protein; Septins; Part 5. Molecular motors and associated proteins; Introduction; 5a. Motor proteins; Dynein, axonemal; Dynein, cytoplasmic; Kinesin, bipolar; Kinesin, chromo; Kinesin, conventional; Kinesin, C-terminal motor domain; Kinesin, heteromeric; Kinesin, internal motor domain; Kinsein, monomeric; Kinesin, orphan; Muscle myosin, skeletal; Muscle myosin, scallop; Muscle myosin, smooth; Myosin I; Myosin II, cytoplasmic; Myosin III (NINAC); Myosin V; Myosin VI; Myosin VII; Myosin IX; Myosins, divergent; Myosin, plant; Myosin heavy chain kinases; 5b. Motor-associated proteins; C- and H-proteins; Dynactin complex; Kinectin; Myomesin and M-protein; Paramyosin; Titin; Part 6. Organelle structural proteins; Introduction; Adaptor proteins (AP-1-AP-3); ADP-ribosylation factors (Arfs); Amphiphysin; AP180; Auxilin; Caveolins; Clathrin; Coatomer; Comitin; COPII; Dynamin; Eps15; Gephyrin; Giantin; GM130; GRASP 65; p115; Synaptojanin; Synapsins; Index