In this issue, 39 species new to science are proposed, in addition to 2 new names and a new combination, from the following countries: Mexico, Guatemala, El Salvador, Colombia, Ecuador, Peru, Bolivia, and Venezuela. Twenty-five authors and co-authors have participated, as well as 17 illustrators and 42 photographers. With this issue nearly all of the species of the Macrostachyum Group in Epidendrum are covered, comprising now 46 published species, which had been hitherto lumped under Epidendrum macrostachyum Lindl. This group of species is Andean, from Bolivia north to Colombia and adjacent Venezuela, with a couple of species in the higher mountains of Panamá and Costa Rica. Being mostly very similar, the species are best recognized by a combination of the shape of leaves, colour of flowers, shape of petals and lip, and the size of the floral bracts.