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Academic & Professional Books  Organismal to Molecular Biology  Genetics

Imaginal Discs The Genetic and Cellular Logic of Pattern Formation

By: Lewis I Held
460 pages, Figs, tabs
Imaginal Discs
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  • Imaginal Discs ISBN: 9780521584456 Hardback May 2002 Usually dispatched within 5 days
Price: £207.00
About this book Contents Customer reviews Related titles

About this book

Many of the 14,000 genes of Drosophila are involved in the development of imaginal discs. These hollow sacs of cells make adult structures during metamorphosis, and their study is crucial to comprehending how a larva becomes a fully-functioning fly. This book examines the genetic circuitry of the well-known 'fruit fly', tackling questions of cell assemblage and pattern formation, of the hows and the whys behind the development of the fly. After an initial examination of the proximity versus pedigree imperatives, the book delves into bristle pattern formation and disc development, with entire chapters devoted to the leg, wing, and eye. Extensive appendices include a glossary of protein domains, catalogues of well-studied genes, and an outline of signaling pathways. More than 30 wiring diagrams among over 60 detailed schematics clarify the text. No student or practising scientist engaged in the study of Drosophila genetics should be without this comprehensive reference.


Preface; 1. Cell lineage versus intercellular signaling; 2. The bristle; 3. Bristle patterns; 4. Origin and growth of discs; 5. The leg disc; 6. The wing disc; 7. The eye disc; 8. Homeosis; Epilogue; Appendices; References; Index.

Customer Reviews

By: Lewis I Held
460 pages, Figs, tabs
Media reviews
'... figures and their legends ... packed full of more information than most text books. The appendices, especially the compendia of genes affecting particular processes are useful. Imaginal Discs would be a useful read for anyone interested in pattern formation generally, and should be required for workers in Drosophila patterning.' BioEssays 'How wonderful to have such a complete guide and extensive review of imaginal disc development. The comprehensive nature of this book makes it an essential reference. ... a wonderful teaching resource. ... read and enjoy the history behind the models!' Genetical Research
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