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In Pursuit of the Gene: From Darwin to DNA

Popular Science

By: James Schwartz

310 pages, 42 halftones

Harvard University Press

Paperback | Nov 2009 | #181334 | ISBN-13: 9780674034914
Availability: Usually dispatched within 4 days Details
NHBS Price: £14.95 $20/€17 approx
Hardback | Apr 2008 | #173884 | ISBN-13: 9780674026704
Availability: Usually dispatched within 4 days Details
NHBS Price: £22.95 $30/€26 approx

About this book

The mystery of inheritance has captivated thinkers since antiquity, and the unlocking of this mystery - the development of classical genetics - is one of humanity's greatest achievements. This great scientific and human drama is the story told fully and for the first time in this book.

Acclaimed science writer James Schwartz presents the history of genetics through the eyes of a dozen or so central players, beginning with Charles Darwin and ending with Nobel laureate Hermann J. Muller. In tracing the emerging idea of the gene, Schwartz deconstructs many often-told stories that were meant to reflect glory on the participants and finds that the "official" version of discovery often hides a far more complex and illuminating narrative. The discovery of the structure of DNA and the more recent advances in genome science represent the culmination of one hundred years of concentrated inquiry into the nature of the gene. Schwartz's multifaceted training as a mathematician, geneticist, and writer enables him to provide a remarkably lucid account of the development of the central ideas about heredity, and at the same time bring to life the brilliant and often eccentric individuals who shaped these ideas.

In the spirit of the late Stephen Jay Gould, this book offers a thoroughly engaging story about one of the oldest and most controversial fields of scientific inquiry. It offers readers the background they need to understand the latest findings in genetics and those still to come in the search for the genetic basis of complex diseases and traits.

Understanding the nature of genetic inheritance was essential for evolution to be accepted as the dominant paradigm in biology. In a masterful work, science writer Schwartz looks at the science and the personalities behind that understanding, ranging from Darwin's belief in pangenesis to explain the inheritance of physical variations to Hermann Muller's Nobel Prize-winning work on X-rays and genetic mutation. Although he discusses the contributions of such luminaries as Francis Galton, William Bateson, Gregor Mendel, Hugo de Vries and Thomas Hunt Morgan, Schwartz provides far more than character sketches. In a thoroughly accessible manner, he offers insight into the critical experiments each undertook and allows readers to share the excitement of discovery. He also does a fabulous job of demonstrating the social nature of science, showing how competition often leads to unseemly actions and how the unwillingness to part with a favorite theory leads to an idiosyncratic interpretation of data. Schwartz illustrates how, despite all of this, science continues to make progress and our understanding of the world continues to grow. Although the history of genetics has been covered many times before, Schwartz brings unbridled energy, strong writing and a fresh perspective. Publishers Weekly (starred review) 20080211 Often described as a noble quest for the truth, science can also be messy and duplicitous--never more so, as this book reveals, than in the search for the key to heredity, the gene. Yet rarely has science involved such inspiring and passionate figures--Mendel, Bateson, Morgan, Muller--whose names we may recognize but whose personal tales are relatively little told. Here is the 100-year story of genetics with the setbacks and breakthroughs carefully explained, and the human story--including spells in Soviet prison camps and suicide attempts--thrillingly evoked. -- Rowan Hooper New Scientist 20080517 What distinguishes Schwartz's account is his impeccable scholarship, based on many primary sources, and his ability to keep the narrative moving, interweaving discoveries with the strong and eccentric personalities who made them...In Pursuit of the Gene should be required reading for all biologists unfamiliar with the history of genetics. Schwartz shows how quickly science can advance when a group of first-class minds encounters a fertile but unploughed field. -- Jerry A. Coyne Nature 20080626 What makes this account so novel and definitely worth reading is its fine study of character, based primarily on a sensitive reading of original documents. As a result, some of the leading well-known figures in the history of genetics come across in a very different light that leads to a rethinking of existing historical understanding. -- Vassiliki Betty Smocovitis Journal of Heredity 20091101


List of Illustrations Preface 1. Viva Pangenesis 2. Reversion to the Mean 3. Galton's Disciples 4. Pangenes 5. Mendel 6. Rediscovery 7. Mendel Wars I 8. Cell Biology 9. Sex Chromosomes 10. The Fly Room 11. Oenothera Reconsidered 12. X-rays 13. Mendel Wars II Epilogue Notes Index

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James Schwartz is an independent scholar and writer living in Brookline, Massachusetts.

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