Active, accessible, and assuming no prior knowledge: the ideal text for biologists encountering bioinformatics for the first time.
A vast amount of biological information about a wide range of species has become available in recent years as technological advances have significantly reduced the time it takes to sequence a genome or determine a novel protein structure. This text describes how bioinformatics can be used as a powerful set of tools for retrieving and analysing this biological data, and how bioinformatics can be applied to a wide range of disciplines such as molecular biology, medicine, biotechnology, forensic science and anthropology.
Fully revised and updated, the fifth edition of Introduction to Bioinformatics contains a host of new material including new content on next generation sequencing, function prediction, sequence assembly, epigenomics, the bioinformatics of gene editing, and the effects of single nucleotide variants.
Written primarily for a biological audience without a detailed prior knowledge of programming, Introduction to Bioinformatics is the perfect introduction to the field of bioinformatics, providing friendly guidance and advice on how to use various methods and techniques. Furthermore, frequent examples, self-test questions, problems, and exercises are incorporated throughout the text to encourage self-directed learning.
2: From genetics to genomes
3: The panorama of life
4: Alignments and Phylogenetic Trees
5: Structural bioinformatics and drug discovery
6: Scientific publications and archives: media, content, access, and presentation
7: Artificial intelligence and machine learning
8: Introduction to systems biology
9: Metabolic pathways
10: Control of organization and organization of control
Arthur M. Lesk is Professor of Biochemistry and Molecular Biology at The Pennsylvania State University, USA.
Reviews of earlier editions:
"This is an excellent textbook that would appeal to those new to the field as well as those who have prior experience in the subject area. The mixture of narrative and clear diagrammatic representation has been skilfully woven together to produce a rich contextualised resource."
– Dr Don Green, London Metropolitan University
"It provides an excellent introduction to the subject and balances a historical perspective with recent developments. Although it is easily accessible, in places it doesn't shy away from more complex, but relevant computational analysis."
– Dr Colin Sharpe, University of Portsmouth
"[It] discusses the key concepts well and in an easy to understand format, with useful exercises and examples of real-world applications."
– Dr Dallas Roulston, Middlesex University London
"The writing style is appropriate, consistent and very clear."
– Dr. Lorena Fernández-Martínez, Edge Hill University
"My "go to" introductory text on bioinformatics. Accessible, yet intelligent."
– Dr Lee J. Byrne, Canterbury Christ Church University