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Undergraduate textbook focusing on bioinformatics from an evolutionary point of view. Covers the following topics: gene finding by linkage disequillibrium mapping, restriction maps, DNA analysis and forensic medicine, sequence data bases, introduction to and application of pairwise alignments, Bayesian statistics, detecting sequence patterns, DNA-protein interaction, multiple alignments, phylogenetic analysis, distance methods, parismony and likelyhood, neutral theory, and coalescent theory. The volume contains exercises, questions and answers to selected problems, an introduction to coalescent theory, and an appendix with essentials of probability theory.