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Since Darwin, people have speculated about the evolutionary relationships among dissimilar species, including our connections to the diverse life forms known as microbes. In the 1970s biologists discovered a way to establish these kinships. This new era of exploration began with Linus Pauling's finding that every protein in every cell contains a huge reservoir of evolutionary history. His discovery opened a research path that has changed the way biologists and others think about the living world. In Kin: How We Came to Know Our Microbe Relatives John L. Ingraham tells the story of these remarkable breakthroughs. His original, accessible history explains how we came to understand our microbe inheritance and the relatedness of all organisms on Earth.
Among the most revolutionary scientific achievements was Carl Woese's discovery that a large group of organisms previously lumped together with bacteria were in fact a totally distinct form of life, now called the archaea. But the crowning accomplishment has been to construct the Tree of Life – an evolutionary project Darwin dreamed about over a century ago. Today, we know that the Tree's three main stems are dominated by microbes. The nonmicrobes – plants and animals, including humans – constitute only a small upper branch in one stem.
Knowing the Tree's structure has given biologists the ability to characterize the complex array of microbial populations that live in us and on us, and investigate how they contribute to health and disease. This knowledge also moves us closer to answering the tantalizing question of how the Tree of Life began, over 3.5 billion years ago.
I. Discovering the Tree of Life
1. The Tree’s Microbial Branches
2. Relationships among Organisms
3. Enter DNA
4. The Rosetta Stone
5. From the Tree’s Roots to Its Branches
II. Doubts and Complications
6. Genes from Neighbors
7. Can the Receiving Cell Say No?
8. Can the Tree Be Trusted?
III. Understanding the Tree of Life
9. The Tree’s Ecological Fruit
10. The Tree’s Beginnings
John L. Ingraham is Professor of Microbiology, Emeritus, at the University of California, Davis.
"In a delightfully personal yet accurate style, Ingraham describes the events and personalities that brought us the 'Tree of Life,' the representation that encapsulates the relatedness of all organisms of Earth. Readers will be educated while they are entertained as they explore fascinating aspects of life discovered through the study of our microbial relatives."
– Roberto Kolter, Harvard University
"One of the grandest achievements of modern biology has been the unraveling of the relationships among the many kinds of life and the determination of the course of evolution, a great tree of all life. In Kin, prominent microbiologist John Ingraham traces the scientific developments that led to this achievement and some of its ramifications. Along the way, with many personal anecdotes about scientists involved, Ingraham unfolds the history of microbiology and molecular biology, the development of genetic technology, and ideas on the origin of life. Kin is a highly readable account of a remarkable period of scientific progress in biology."
– Norman Pace, University of Colorado