Focusing on the practical applications, this user-oriented guide presents current technologies and strategies for systems-level lipid analysis, going beyond basic research to concentrate on commercial uses of lipidomics in biomarker and diagnostic development, as well as within pharmaceutical chemistry. The editor and authors have experience of the most recent analytical instruments and techniques, allowing them to provide here first-hand practical experience for newcomers to the field. The first half of Lipidomics: Technologies and Applications covers current methodologies, ranging from global to targeted lipidomics and shotgun approaches, while the second part discusses the role of lipidomics in biomedical and pharmaceutical research, covering such diverse fields as inflammation, metabolic syndrome, cardiovascular and neurological disease. Both small and large-scale, high-throughput approaches are discussed, resulting in an invaluable source for academic and industrial research and development.
- Lipidomics Perspective: From Molecular Lipidomics to Validated Clinical Diagnostics
- Lipids in Cells
- High Throughput Molecular Lipidomics
- Multi-Dimensional Mass Spectometry-Based Shotgun Lipidomics
- Targeted Lipidomics: Sphingolipidomics
- Structural Lipidomics
- Imaging Lipids in Tissues by Matrix Assisted Laser Desorption/Ionization Mass Spectrometry
- Lipid Informatics: From a Mass Spectrum to Interactomics
- Lipidomics in Lipoprotein Biology
- Mediator Lipidomics in Inflammation Research
- Lipidomics for Elucidation of Metabolic Syndrome and Related Lipid Metabolic Disorder
- Lipidomics in Atherosclerotic Vascular Disease
- Lipid Metabolism in Neurodegenerative Diseases
- The Tumor Mitochondrial Lipidome and Respiratory Bioenergetic Insufficiency
- Lipidomics for Pharmaceutical Research
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Kim Ekroos currently heads the bioanalytics division at Zora Biosciences in Espoo (Finland). He holds a Ph.D from the Technical University of Dresden (Germany) and has conducted research in the group of Prof. Kai Simons and Andrej Shevchenko at the Max-Planck Institute of Molecular Cell Biology and Genetics in Dresden. Kim has also worked at the European Molecular Biology Laboratory in Heidelberg. He has made major contributions to the advancement of basic research on lipids and their study with advanced mass spectroscopy methods. Kim has also pharmaceutical industry experience from Astra Zeneca where he spent three years successfully developing high-throughput lipidomic methods.