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This state-of-the-art reference addresses lysophospholipids, a special kind of fat that has been found to have a growing number of receptors within the cell and has important, natural roles in the body including normal reproduction, development, maturation, and life. Lysophospholipid Receptors: Signaling and Biochemistry covers the biochemistry, interactions, and signaling of lysophospholipids as well as its potential for producing new therapies for a range of medically important human diseases. Bringing together current knowledge in lysophospholipid signaling, Lysophospholipid Receptors: Signaling and Biochemistry is a must-have for all academic, industrial, and medical school and hospital libraries.
Chapter 1 Lysophosphatidic acid (LPA) receptor signaling
Hope Mirendil, Mu-En Lin, and Jerold Chun
Chapter 2 Sphingosine 1-phosphate (S1P) Receptors
Bongnam Jung and Timothy Hla
Chapter 3 Global gene expression program of lysophosphatidic acid (LPA)-stimulated fibroblasts
Catelijne Stortelers and Wouter H. Moolenaar
Chapter 4 Identification of Direct Intracellular Targets of Sphingosine 1-Phosphate (S1P)
Nitai C. Hait, Sheldon Milstien, and Sarah Spiegel
Chapter 5 Lysophospholipid receptor signaling platforms: The receptor tyrosine kinase-G-protein coupled receptor signaling complex
Nigel J. Pyne and Susan Pyne
Chapter 6 Autotaxin: a unique ecto-type pyrophosphodiesterase with diverse functions
Hiroshi Yukiura and Junken Aoki
Chapter 7 Studies on autotaxin signaling in endocytic vesicle biogenesis and embryonic development using whole embryo culture and electroporation
Masayuki Masu, Seiichi Koike, Takuya Okada, and Kazuko Keino-Masu
Chapter 8 Standardization and Quantification of Lysophosphatidic Acid Compounds by Normal Phase and Reversed Phase Chromatography – Tandem Mass Spectrometry
Jeff D. Moore, Shengrong Li1, David S. Myers, Stephen B. Milne, H. Alex Brown, and Walter A. Shaw
Chapter 9 Sphingosine kinases: Biochemistry, regulation, and roles
Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham, and Stuart M. Pitson
Chapter 10 Functional and physiological roles of sphingosine 1-phosphate transporters
Atsuo Kawahara and Tsuyoshi Nishi
Chapter 11 Lipid phosphate phosphatases and signaling by lysophospholipid receptors
Ganesh Venkatraman and David N. Brindley
Chapter 12 Lipid Phosphate Phosphatases: Recent Progress and Assay Methods
Andrew J. Morris, Susan S. Smyth, Abdel K. Salous, and Andrew D. Renault
Chapter 13 Lysophosphatidic Acid (LPA) Signaling and Cardiovascular Pathology
Susan S. Smyth, Anping Dong, Jessica Wheeler, Manikandan Panchatcharam, and Andrew Morris
Chapter 14 Sphingosine 1-phosphate (S1P) signaling in cardiovascular physiology and disease
Bodo Levkau
Chapter 15 Sphingosine 1-phosphate (S1P) signaling and the vasculature
Christian Waeber
Chapter 16 Regulation of the Nuclear Hormone Receptor PPAR? by Endogenous Lysophosphatidic Acids (LPAs)
Ryoko Tsukahara, Tamotsu Tsukahara, and Gabor Tigyi
Chapter 17 Mechanisms and models for elucidating the cardiac effects of sphingosine 1-phosphate (S1P)
Shigeki Miyamoto, Sunny Yang Xiang, Nicole Purcell, and Joan Heller Brown
Chapter 18 Neural effects of lysophosphatidic acid (LPA) signaling
Nobuyuki Fukushima
Chapter 19 Widespread expression of Sphingosine kinases and Sphingosine-1-phophate (S1P) lyase suggest diverse functions in the vertebrate nervous system
H. Meng and V.M. Lee
Chapter 20 Lysophosphatidic acid and neuropathic pain – demyelination and LPA biosynthesis
Hiroshi Ueda
Chapter 21 Role of lysophosphatidic acid (LPA) in behavioral processes: implications for psychiatric disorders
Guillermo Estivill-Torrús, Luis Javier Santín, Carmen Pedraza, Estela Castilla-Ortega, Fernando Rodríguez de Fonseca
Chapter 22 Sphingosine 1-phosphate (S1P) signaling and lymphocyte egress
Alejandra Mendoza, Lauren A. Pitt, and Susan R. Schwab
Chapter 23 Biology Revealed by Sphingosine 1-phosphate (S1P) Receptor Gene-Altered Mice
Maria L. Allende, Mari Kono, Katerina Alexaki, Christina Giannouli, Jiman Kang, Catherine C. Theisen, Eleanor L. Koerner, and Richard L. Proia
Chapter 24 Role of lysophosphatidic acid (LPA) in the intestine
C. Chris Yun and Peijian He
Chapter 25 Lysophospholipid signaling in female and male reproductive system
Xiaoqin Ye
Chapter 26 The gonads and their magic bullet: lysophosphatidic acid Physiological and toxicological functions of lysophosphatidic acid (LPA) in female and male reproductive systems
Lygia Therese Budnik, Bärbel Brunswig-Spickenheier, Dieter Müller
Chapter 27 Lysophospholipid Regulation of Lung Fibrosis
Barry S. Shea and Andrew M. Tager
Chapter 28 Lysophosphatidic acid (LPA) signaling and bone
Jean Pierre Salles, Sara Laurencin-Dalicieux, Françoise Conte-Auriol, Fabienne Briand-Mésange, and Isabelle Gennero
Chapter 29 Lysophosphatidic acid (LPA) signaling and bone cancer
Olivier Peyruchaud, Marion David, Timothy L. Macdonald, and Kevin R. Lynch
Chapter 30 Understanding the Functions of Lysophosphatidic Acid Receptors in Cancer
Nattapon Panupinthu and Gordon B. Mills
Chapter 31 Lysophosphatidic Acid Receptors in Cancer
Abir Mukherjee, Jinhua Wu, Yongling Gong, and Xianjun Fang
Chapter 32 LPA receptor subtypes LPA1 and LPA2 as potential drug targets
Gretchen Bain and T. Jon Seiders
Chapter 33 Clinical Introduction of Lysophosphatidic Acid (LPA) and Autotaxin Assays
Yutaka Yatomi, Koji Igarashi, Kazuhiro Nakamura, Ryunosuke Ohkawa, Akiko Masuda, Akiko Suzuki, Tatsuya Kishimoto, Hitoshi Ikeda, and Junken Aoki
Chapter 34 Antibodies to bioactive lysophospholipids
Roger A. Sabbadini, Jonathan M. Wojciak, Kelli Moreno, and Barbara Visentin
Index
