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About this book
About this book
Provides a detailed description of microsatellite biology, focusing on their mutation properties, generation, decay, and possible functional roles.
'...it is the most comprehensive volume on microsatellities and has contributions from many excellent researchers' Trends in Ecology and Evolution
1. Microsatellites and other simple sequences; 2. Functional roles of microsatellites and minisatellites; 3. Microsatellites and mutation processes in tandemly repetitive DNA; 4. Mechanistic basis for microsatellite instability; 5. Microsatellite evolution : inferences from population data; 6. A comparative approach to the study of microsatellite evolution; 7. Trinucleotide expansion mutations cause diseases which do not conform to Mendelian expectations; 8. Mutation and migration in models of microsatellite evolution; 9. The coalescent and microsatellite variability; 10. Estimating the age of mutations using variation of linked markers; 11. Statistics of microsatellite loci : Estimation of mutation rate and pattern of population expansion; 12. Using microsatellites to measure the fitness consequences of inbreeding and outbreeding; 13. Microsatellites in conservation genetics; 14. Microsatellites and the reconstruction of the history of human populations; 15. Forensic applications of microsatellite markers; 16. Tracking linkage disequilibrium in advanced population with microsatellite loci; 17. Microsatellite markers in complex disease : mapping disease - associated regions within the human MHC; 18. Microsatellites : a neutral marker to infer selective sweeps; 19. Y chromosome microsatellite haplotypes and the history of Samoyed-speaking populations in N-W Siberia; 20. MS analysis of human tumours
352 pages, 3 b/w illus, figs, tabs
"This excellent book makes a strong case for microsatellites...several of the book's editors and contributors have been active in developing these genetic distance measures. This book will provide an excellent introduction and reference for those using tandem repeats in their research." -- The Quarterly Review of Biology, Vol 76, Mar 2001