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Classic biostatistics, a branch of statistical science, has as its main focus the applications of statistics in public health, the life sciences, and the pharmaceutical industry. Modern biostatistics, beyond just a simple application of statistics, is a confluence of statistics and knowledge of multiple intertwined fields. The application demands, the advancements in computer technology, and the rapid growth of life science data (e.g., genomics data) have promoted the formation of modern biostatistics.
There are at least three characteristics of modern biostatistics: (1) in-depth engagement in the application fields that require penetration of knowledge across several fields, (2) high-level complexity of data because they are longitudinal, incomplete, or latent, and (3) dynamics, as the speed of development in methodology and analyses has to match the fast growth of data with a constantly changing face.
This book is written for researchers, (bio)statisticians, and scientists who are interested in quantitative analyses. The goal is to introduce modern methods in biostatistics and help researchers and students quickly grasp key concepts and methods. Many methods can solve the same problem and many problems can be solved by the same method, which becomes apparent when those topics are discussed in this single volume.
- Multiple-Hypothesis Testing Strategy
- Pharmaceutical Decision and Game Theory
- Noninferiority Trial Design
- Adaptive Trial Design
- Missing Data Imputation and Analysis
- Multivariate and Multistage Survival Data Modeling
- Data Mining and Signal Detection
- Monte Carlo Simulation
- Bayesian Methods and Applications
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Mark Chang Ph.D. is the executive director of Biostatistics and Data Management, AMAG Pharmaceuticals, with over 15 years of experience as a statistician in the field of clinical trials. He is a co-founder of the International Society for Biopharmaceutical Statistics, an executive member of the ASA Biopharmaceutical Section, and a member of the Expert Panel for the Networks of Centres of Excellence, Canada. He is a co-chair of the Biotechnology Industry Organization Adaptive Design Working Group.
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