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In this book, for the first time, the different molecular and cellular aspects of enzymology are presented together. Until now, there has been no book available in which these different aspects are treated in the same volume. In addition, besides the theoretical developments, this book provides a wealth of practical information for experimentalists.
Thermodynamic laws -- Notion of chemical equilibrium.- Equilibrium of protein --ligands association The living organisms, open systems.- Chemical kinetics.- Experimental methods to study the enzyme reactions Origin of enzymes and evolution.- Formation of the functional structure of enzymes : co- and post-translational events.- Topology of the active center of enzymes.- Formation of the enzyme-substrate complexes.- Catalytic mechanisms.- Examples of structure-function relationships in enzyme systems.- Regulation through non-covalent interactions.- Covalent regulations.- Multifunctional enzymes, multienzyme complexes and metabolic channeling Cellular localisation and compartmentation.- Kinetics of enzyme reactions catalyzed by immobilized enzymes.- Theory of the control of metabolic pathways.
From the reviews: "The entire text would provide the best picture of the current state of enzymology, each chapter is understandable on its own. Thus, this work can be used as a reference source for specific topics of interest. Summing Up: Recommended. Upper-division undergraduate through professional collections." (L. J. Liotta, Choice, Vol. 48 (2), October, 2010)
