For nearly a quarter century Molecular Biology of the Cell has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter).
The hallmark features of Molecular Biology of the Cell have been retained, such as its consistent and comprehensive art program, clear concept headings, and succinct section summaries. Additionally, in response to extensive feedback from readers, the Fifth Edition now includes several new features.
It is now more portable. Chapters 1-20 are printed and Chapters 21-25, covering multicellular systems, are provided as pdf files on a DVD-ROM which accompanies Molecular Biology of the Cell.
And for the first time, Molecular Biology of the Cell now contains end-of-chapter questions. These problems, written by John Wilson and Tim Hunt, emphasize a quantitative approach and the art of reasoning from experiments, and they will help students review and extend their knowledge derived from reading Molecular Biology of the Cell.
Please note that a separate problems book and reference edition, with the text of chapters 21-25 printed, are also available.
"Throughout the book, emphasis is placed not just on what 'we know' but also on 'how we know' and 'what remains to be discovered'- important for engaging and enthusing students [...] A quarter of a century after the first edition revolutionised cell biology textbooks, the new edition is as fresh, comprehensive and above all, as readable as ever [...] Like its predecessors, this is a superb textbook for advanced undergraduate and postgraduate students."
- British Society for Developmental Biology Newsletter, Summer 2008, Vol. 29, No. 1
"Professors, lecturers, and instructors will find the fifth edition of the book Molecular Biology of the Cell and its accompanying Problems Book to be an excellent choice for guiding their students through the maze of the cell's molecular structures and biochemical processes [...] With countless colorful illustrations and a large number of photographs and tables, reading the text becomes not only an educational experience, but also a highly enjoyable one for those students who wish to discover the inner workings of the magnificent cellular machine [...] Educators will also find the DVD-ROM to be a rich electronic resource when compiling their lectures [...] No less important is the Problems Book, which contains numerous exercises and questions that are an integral part of the learning process, and that teachers, instructors, and students are sure to appreciate."
- The Quarterly Review of Biology, September 2008, Volume 83, Number 3
Part I: Introduction to the Cell
1. Cell and Genomes
2. Cell Chemistry and Biosynthesis
Part II: Basic Genetic Mechanisms
4. DNA and Chromosomes
5. DNA Replication, Repair and Recombination
6. How Cells Read the Genome: From DNA to Protein
7. Control of Gene Expression
Part III: Methods
8. Manipulating Proteins, DNA, and RNA
9. Visualizing Cells
Part IV: Internal Organization of the Cell
10. Membrane Structure
11. Membrane Transport of Small Molecules and the Electrical Properties of Membranes
12. Intracellular Compartments and Protein Sorting
13. Intracellular Vesicular Traffic
14. Energy Conversion: Mitochondria and Chloroplasts
15. Cell Communication
16. The Cytoskeleton
17. The Cell Cycle and Programmed Cell Death
18. The Mechanics of Cell Division
Part V: Cells in Their Social Context
19. Cell Junctions, Cell Adhesion, and the Extracellular Matrix
20. Germs Cells and Fertilization
21. Development of Multicellular Organisms
22. Histology: The Lives and Deaths of Cells in Tissues
24. The Adaptive Immune System
25. Pathogens, Infection, and Innate Immunity
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