Books  Ecological & Biological Sciences  Animal & General Biology  Genetics 

Molecular Genetics of Recombination

Series: Topics in Current Genetics Volume: 17

Edited By: Andres Aguilera and Rodney Rothstein

545 pages, 70 illus


Hardback | Apr 2007 | #165972 | ISBN-13: 9783540710202
Availability: Usually dispatched within 1-2 weeks Details
NHBS Price: £329.99 $430/€376 approx

About this book

Genetic recombination is an important process involved in shaping the genetic make up of progeny. Increasingly, it has become evident that recombination is a DNA repair pathway crucial during DNA replication in vegetatively growing cells. It plays a critical role in preserving the integrity of the genome by mediating the repair of DNA damage, which can occur during normal cellular metabolism as a result of oxidative stress, transcription, replication fork stalling or breakdown, or after the exposure to DNA damaging agents. Until recently, much of our knowledge on the mechanisms of genetic recombination has come from studies of prokaryotic and simple eukaryotic fungal systems. However, these studies have now been significantly extended to mammals, such that a comparative picture of the general factors and mechanisms of genetic recombination is beginning to emerge. Detailed genetic and biochemical studies have led to the isolation and characterization of many of the recombination-repair proteins in E. coli and S. cerevisiae, which in turn has led to the identification of homologues in human cells. The link between recombination defects and recombination proteins in a number of tumors as well as in human hereditary syndromes makes genetic recombination a cellular process of key importance not only in basic biology but also in biomedical studies.


Genetics of Recombination in the Model Bacterium Escherichia coli.- Homologous Recombination in Low dC + dG Gram-Positive Bacteria.- The Bacterial RecA Protein: Structure, Function, and Regulation.- Biochemistry of Eukaryotic Homologous Recombination.- DNA Helicases in Recombination.- Holliday Junction Resolution.- Replication Forks and Replication Checkpoints in Repair.- Sister Chromatid Recombination.- Mating-Type Switching in S. pombe.- Multiple Mechanisms of Repairing Meganuclease-Induced Double-Strand DNA Breaks in Budding Yeast.- The Cell Biology of Mitotic Recombination in Saccharomyces cerevisiae.- The cell biology of Homologous Recombination.- BRCA2: Safeguarding the Genome Through Homologous Recombination.- Meiotic Recombination.- Site-specific Recombination.- V(D)J Recombination: Mechanism and Consequences.- Nonhomologous End-Joining: Mechanisms, Conservation, and Relationship to Illegitimate Recombination.-

Write a review

There are currently no reviews for this book. Be the first to review this book!

Bestsellers in this subject

Environmental DNA

NHBS Price: £34.99 $46/€40 approx

The Tangled Tree

NHBS Special Offer Price: £17.99 £19.99 (Save £2.00) $23/€20 approx (ends 31/12/2018)

Practical Streptomyces Genetics

NHBS Price: £104.00 $136/€118 approx

The End of Sex and the Future of Human Reproduction

NHBS Price: £14.95 $19/€17 approx

Molecular Population Genetics

NHBS Price: £54.99 $72/€63 approx

VAT: GB 407 4846 44
NHBS Ltd is registered in England and Wales: 1875194