Cells of all living organisms have the ability to respond to altered nutritional conditions. They have developed mechanisms to sense nutrient availability and to produce appropriate responses, which involve changes in gene expression and the production or degradation of certain enzymes and other proteins. In recent years, the understanding of nutrient-induced signal transduction has greatly advanced and the emerging picture is that nutrient signalling mechanisms evolved early in evolution. This book provides a detailed presentation and comparison of the key nutritional regulatory mechanisms in lower as well as higher eukaryotes, written by recognised experts in this expanding field.
Transcriptional Regulatory Mechanisms for the Response to Amino Acid Deprivation of Mammalian Cells.- Nutrient Sensing in Animal Cells and Integration of Nutrient and Endocrine Signalling Pathways.- Antagonists of the TOR Pathway in Animal Cells.- Nutrients as Regulators of Endocrine and Neuroendocrine Secretion.- Nutrient Signalling Through Mammalian GCN2.- Nutrient Control of Dimorphic Growth in Saccharomyces cerevisiae.- Regulation of the Yeast General Amino Acid Control Pathway in Response to Nutrient Stress.- Tor-Signalling and Tor-Interacting Proteins in Yeast.- Integrated Regulation of the Nitrogen-Carbon Interface.- Glucose Regulation of HXT Gene Expression in the Yeast Saccharomyces cerevisiae.- Integration of Nutrient Signalling Pathways in the Yeast Saccharomyces cerevisiae.