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The series of review articles presented in this book summarizes the recent state-of-the- art in lipid research in a comprehensive way. The authors provide a general overview of this field and draw the reader's attention to the most recent investigation. Biochemical, cell biological and biophysical aspects of the four major groups of lipids in eukaryotic cells, namely glycerophospholipids, sterols, sphingolipids and storage lipids, are reported and discussed. The experimental systems addressed are mammalian, plant and yeast cells as the most prominent and currently best studied systems in lipid biochemistry, cell and molecular biology.
Introduction: Lipids: Cellular Glue? or are They More Than That?- Phospholipid Synthesis in Mammalian Cells.- Phospholipid Synthesis and Dynamics in Plant Cells.- Biogenesis and Cellular Dynamics of Glycerophospholipids in the Yeast Saccharomyces cerevisiae.- Defects in Cholesterol Biosynthesis.- Sterol Metabolism and Functions in Higher Plants.- Sterol Biochemistry and Regulation in the Yeast Saccharomyces cerevisiae.- Mammalian ACAT and DGAT2 Gene Families.- Biosynthesis and Compartmentation of Triacylglycerol in Higher Plants.- Mechanisms and Mediators of Neutral Lipid Biosynthesis in Eukaryotic Cells.- Sphingosine-1-phosphate Metabolism in Mammalian Cell Signalling.- Plant Sphingolipids.-Baker?s Yeast: a Rising Foundation for Eukaryotic Sphingolipid-mediated Cell Signaling.