Molecular Physiology of Growth

About this book

How do hormones and growth factors regulate animal growth in the developing embryo and after injury? What processes at the molecular level determine the growth patterns of different tissues?

In this diverse synthesis of recent research the regulation of growth in response to environmental and genetic stimuli is discussed at the level of the animal, tissues and cells. Contrasts are drawn between regulation in foetal and adult tissues, and in different tissues such as the CNS, bone and muscle. Functional chapters focus on the molecular links between mechanical tension and muscle growth, for example, while other chapters review the roles of specific molecules such as growth hormone.

This state-of-the-art review will be of significant interest to graduate students and research scientists in the fields of animal growth, endocrinology and cell biology.

First published in 1996.

Contents

1. Role of growth hormone in growth regulation D. J. Flint, K. Akinsaya, P. J. Crilly, P. Johnston, and D. Wynick; 2. Insulin-like growth factor-1 and its binding proteins: role in postnatal growth J. M. Pell, and J. Glassford; 3. Growth factor interactions in epiphyseal chondrogenesis D. J. Hill; 4. Developmental changes in the CNS response to injury: growth factor and matrix interactions A. Logan; 5. The role of transforming factor ss during cardiovascular development M. C. Dickson, J. S. Martin, and R. J. Ackhurst; 6. Tenascin: an extracellular matrix protein associated with bone growth E. J. Mackie, and S. Ramsey; 7. Compartmentation of protein synthesis, mRNA targeting and c-myc expression during mucle hypertrophy and growth J. Hesketh; 8. The role of mechanical tension in regulating muscle growth and phenotype P. T. Loughna, and C. Brownson; 9. The prenatal influence on postnatal muscle growth N. C. Stickland, and C. M. Dwyer; 10. Genomic imprinting and intrauterine growth retardation G. E. Moore, P. R. Bennett, Z. Ali, R. U. Khan, and J. I. Vaughan.

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