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The nuclear structure is not always stable but varies from hour to hour. Thus, it is important to capture dynamic changes of the structure and function from the viewpoint of molecular dynamics. Using the latest visualizing techniques in combination with biochemical and molecular biological methods, researchers from a broad range of fields of knowledge, including chromosomal structure, nuclear transfer, RNA, nuclear membrane, transcription, and nuclear domain structures, provide an overview of the nuclear structure and current issues in nuclear dynamics. The dynamics of nuclear structures described in this book furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.
Preface: Overview of Nuclear Organization and Nuclear Dynamics Kunio Takeyasu 1. Visual Biology of Nuclear Dynamics: From Micro- to Nano-dynamics of Nuclear Components Shige H. Yoshimura 2. Nuclear Envelope: Nanoarray Responsive to Aldosterone Hans Oberleithner 3. Mitotic Chromosome Segregation Control Yu Xue, Chuanhai Fu, Yong Miao, Jianhui Yao, Zhen Dou, Jie Zhang, Larry Brako, and Xuebiao Yao 4. Breakdown and Reformation of the Nuclear Envelope Tokuko Haraguchi and Yasushi Hiraoka 5. Functional Organization and Dynamic Aspects of Nucleoli During the Cell Cycle Takuya Saiwaki and Yoshihiro Yoneda 6. Dynamics, Roles, and Diseases of the Nuclear Membrane, Lamins, and Lamin-binding Proteins Tsuneyoshi Horigome, Yasuhiro Hirano, and Kazuhiro Furukawa 7. Gene Selectors Consisting of DNA-Binding Proteins, Histones, and Histone-Binding Proteins Regulate the Three Major Stages of GeneExpression Shinsuke Muto and Masami Horikoshi 8. Dynamic Chromatin Loops and the Regulation of Gene Expression Hiroshi Kimura and Peter R. Cook 9. Nuclear Architecture: Topology and Function of Chromatin- and Non-Chromatin Nuclear Domains Satoshi Tashiro, Marion Cremer, Irina Solovei, and Thomas Cremer 10-1. Regulation of Chromatin Structure by Curved DNA: How Activator Binding Sites Become Accessible Takashi Ohyama 10-2. Actin-Related Proteins Involved in Nuclear and Chromatin Dynamics Masahiko Harata 10-3. Effects of 5-Bromodeoxyuridine on Chromatin Structure Dai Ayusawa 10-4. Transcriptional Modulation by Nuclear Matrix Protein P130/MAT3 Associated with MAR/SAR Yasuhide Hibino, Tatsuhiro Usui, and Koichi Hiraga 10-5. Breaking and Tessellating the Contiguous Nuclear Genome Kojiro Ishii Perspective--toward understanding the in situ genome function Kyosuke Nagata