We are in the midst of a revolution. It is a scientific revolution built upon the tools of molecular biology, with which we probe and prod the living world in ways unimaginable a few decades ago. Need to track a bacterium at the root of a hospital outbreak? No problem: the offending germ's complete genetic profile can be obtained in 24 hours. We insert human DNA into E. coli bacteria to produce our insulin.
It is natural to look at biotechnology in the 21st century with a mix of wonder and fear. But biotechnology is not as 'unnatural' as one might think. All living organisms use the same molecular processes to replicate their genetic material and the same basic code to 'read' their genes. The similarities can be seen in their DNA. Here, John Archibald shows how evolution has been 'plugging-and-playing' with the subcellular components of life from the very beginning and continues to do so today. For evidence, we need look no further than the inner workings of our own cells. Molecular biology has allowed us to gaze back more than three billion years, revealing the microbial mergers and acquisitions that underpin the development of complex life. One Plus One Equals One tells the story of how we have come to this realization and its implications.
1: Life as we don't know it
2: Revolutions in biology
3: The seeds of symbiosis
4: Molecular rulers of life's kingdoms
5: Bacteria becomes organelles: an insider's take
6: The complex cell: when, who, where, and how?
7: Green evolution, green revolution
8: Back to the future
John Archibald is a Professor in the Department of Biochemistry & Molecular Biology at Dalhousie University, in Halifax, Nova Scotia, Canada. He is a Fellow of the Canadian Institute for Advanced Research, Program in Integrated Microbial Biodiversity, and was a Visiting By-Fellow at Churchill College, University of Cambridge, UK, in 2012. He received his Ph.D. from Dalhousie University in 2001 and returned as a faculty member in 2003 after holding Izaak Walton Killam and Canadian Institutes of Health Research post-doctoral fellowships at the University of British Columbia. He is an Associate Editor for Genome Biology and Evolution and an Editorial Board Member of various journals, including Current Biology, Eukaryotic Cell and BMC Biology.
"One Plus One Equals One is an eloquent account, at times verging on the poetic. With serious scholarship, it illuminates a rare scientific endeavour."
– Nancy A. Moran, Nature