Peptides: Chemistry and Biology

About this book

Peptides play a decisive role in many physiological processes, whether as neurotransmitters, hormones or antibiotics. The rapid developments in peptide research over the past few decades make it almost impossible for newcomers to gain an overview. This means an easily comprehensible yet concise introduction is vital. This unique work covers all the important aspects of this wide-ranging field in one handy volume. On the basis of the fundamental chemical and structural properties of peptides, this reference runs the gamut from analysis, the occurrence and biological importance of peptides, via chemical, biochemical and genetic methods of peptide synthesis, right up to peptide libraries, peptide design and their role in drug research. Yet this book offers much more than a mere overview of the latest level of research. An encyclopedic appendix with valuable data on more than 500 biological relevant peptides and proteins, a comprehensive register and details of further literature references make this the ideal reference for all questions regarding peptide research. For newcomers and specialists alike.

Contents

INTRODUCTION AND BACKGROUND FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES Definitions and main conformational features of the peptide bond Building blocks, classification and nomenclature Analysis of the covalent structure of peptides and proteins Three dimensional structure Methods of structural analysis BIOLOGICALLY ACTIVE PEPTIDES Occurrence and biological roles Biosynthesis Selected bioactive peptide families PEPTIDE SYNTHESIS Principles and objectives Protection of functional groups Peptide bond formation Racemization during synthesis Solid phase peptide synthesis (SPPS) Biochemical synthesis SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS Strategy and tactics Synthesis in solution Optimized strategies on polymeric support Ligation of unprotected peptide segments SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES Cyclopeptides Cystine peptides Glycopeptides Phosphopeptides Lipopeptides Sulfated peptides PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, PEPTIDOMIMETICS Peptide design Modified peptides Peptidomimetics Pseudobiopolymers Macropeptides and de novo design of peptides and proteins COMBINATORIAL PEPTIDE SYNTHESIS Parallel synthesis Synthesis of mixtures APPLICATION OF PEPTIDES AND PROTEINS Protein pharmaceuticals Large scale peptide synthesis Peptide pharmaceuticals Peptide drugs and new drug assays Glossary Index

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