Edited By: Gordon Roberts and Lu Yun Lian
366 pages, ilustrations
Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful technique in structural biology for obtaining high resolution 3-D structures of proteins, second only, and complementary to X-ray crystallography. Molecules are studied in solution, where conditions are closer to what is found in the cell. It is the primary technique used to obtain information on intrinsically disordered (unfolded) proteins, since these proteins will not crystallize easily.
The aim of this book is to provide the newcomer to NMR techniques with practical guidance on how to choose the right experiment, how to carry out the experiment, and how to analyse the resulting spectra. Those who are familiar with the chemical applications of NMR will also find it helpful in describing the special requirements of proteins.
List of Contributors
Introduction (Lu-Yun Lian & Gordon Roberts)
1 Sample Preparation, Data Collection and Processing (Frederick W. Muskett)
2 Isotope Labelling (Mitsuhiro Takeda and Masatsune Kainosho)
3 Resonance Assignments (Lu-Yun Lian and Igor L. Barsukov)
4 Measurement of Structural Restraints (Geerten Vuister, Nico Tjandra, Yang Shen, Alex Grishaev, and Stephan Grzesiek)
5 Calculation of Structures from NMR Restraints (Peter Guntert)
6 Paramagnetic Tools in Protein NMR (Peter H.J. Keizers and Marcellus Ubbink)
7 Structural and Dynamic Information on Ligand Binding (Gordon C.K. Roberts)
8 Macromolecular Complexes (Paul C. Driscoll)
9 Studying Partially Folded and Intrinsically Disordered Proteins using NMR Residual Dipolar Couplings (Malene Ringkjobing Jensen, Val#ry Ozenne, Loic Salmon, Gabrielle Nodet, Phineus Markwick, Pau Bernad# and Martin Blackledge)
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