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This book introduces the basic concepts and methods that are useful in the statistical analysis and modeling of the DNA-based marker and phenotypic data that arise in agriculture, forestry, experimental biology, and other fields. It concentrates on the linkage analysis of markers, map construction and quantitative trait locus (QTL) mapping, and assumes a background in regression analysis and maximum likelihood approaches. The strength of this book lies in the construction of general models and algorithms for linkage analysis, as well as in QTL mapping in any kind of crossed pedigrees initiated with inbred lines of crops.
From the Reviews: "[I]t is a big help and guidance in the field of statistical developments for genetic mapping, synthesised all in one volume helping to build a bridge between genetics and statistics." (Lutz Bunger, Genetic Research, 89, 2007) "...[T]his is an ideal book for a young researcher looking for an exciting and developing field to get into." (International Statistics Review, April 2008)
Basic Genetics.- Basic Statistics.- Linkage Analysis and Map Construction.- A General Model for Linkage Analysis in Controlled Crosses.- Linkage Analysis with Recombinant Inbred Lines.- Linkage Analysis for Distorted and Misclassified Markers.- Special Considerations in Linkage Analysis.- The Structure of QTL Mapping.- Marker Analysis of Phenotypes.- Regression-Based Interval Mapping.- Maximum Likelihood Interval Mapping.- Threshold and Precision Analysis.- Composite QTL Mapping.- QTL Mapping in Outbred Pedigrees.
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