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The Chemical Synthesis of Peptides

By: J Jones

230 pages, Figs

Oxford University Press

Paperback | Apr 1994 | #46076 | ISBN: 0198558392
Availability: Usually dispatched within 2-3 weeks Details
NHBS Price: £89.99 $118/€102 approx
Hardback | #46075 | ISBN-13: 9780198556435
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About this book

Peptides have diverse applications in medicine, and their synthesis by chemical methods is an important and rapidly growing area of research interest. The emphasis throughout this book is on the chemical principles behind the more important methods of peptide synthesis, and it provides a critical, concise, and up-to-date survey of the field. The book begins by covering the basic principles and the chemistry of peptide synthesis. Later chapters look at strategies and techniques used for synthesizing various types of peptide; they are illustrated with carefully selected case studies which highlight the many difficulties involved and the ways in which they can be overcome. This paperback edition includes a fully updated literature guide, and will provide both beginning and established researchers with a valuable account of this important field.

written with elegance and precision, by an expert in the area of peptide chemistry. Aimed at the research chemist, this book will be enjoyed by the expert while being invaluable to the less experienced. Pat Bailey in the Times Higher Education Supplement This is a good, plain, traditional book on the chemistry of peptide synthesis. ...will be especially valuable for new researchers who are contemplating or starting peptide synthesis ... I strongly recommend it. R. C. Sheppard in Chemistry in Britain an overview and appreciation of the field with a choice of language and literary skill which makes the text both intellectual and very pleasant to read ... highly commendable". Karl Folkers, Journal of the American Chemical Society


Part I. Fundamental Chemical Principles; 2. Introduction; 3. *a-Amino-protection; 4. *a-Carboxy-protection; 5. Peptide bond formation; 6. Residue specific considerations; Part II: The Synthesis of Ordinary Peptides and Proteins; 7. Strategy and tactics; 8. Solution peptide synthesis; 9. Solid phase peptide synthesis; 10. Combined approaches and semisynthesis; Part III: The Synthesis of Other Peptides; 11. Conjugated peptides; 12. Simple cyclopeptides; 13. More complex modified peptides; Epilogue; Appendix A. Abbreviations and their uses; Appendix B. A select bibliography and literature guide; Index

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