The Chemical Synthesis of Peptides

About this book

Peptides have diverse applications in medicine, and their synthesis by chemical methods is an important and rapidly growing area of research interest. The emphasis throughout this book is on the chemical principles behind the more important methods of peptide synthesis, and it provides a critical, concise, and up-to-date survey of the field. The book begins by covering the basic principles and the chemistry of peptide synthesis. Later chapters look at strategies and techniques used for synthesizing various types of peptide; they are illustrated with carefully selected case studies which highlight the many difficulties involved and the ways in which they can be overcome. This paperback edition includes a fully updated literature guide, and will provide both beginning and established researchers with a valuable account of this important field.

Contents

Part I. Fundamental Chemical Principles; 2. Introduction; 3. *a-Amino-protection; 4. *a-Carboxy-protection; 5. Peptide bond formation; 6. Residue specific considerations; Part II: The Synthesis of Ordinary Peptides and Proteins; 7. Strategy and tactics; 8. Solution peptide synthesis; 9. Solid phase peptide synthesis; 10. Combined approaches and semisynthesis; Part III: The Synthesis of Other Peptides; 11. Conjugated peptides; 12. Simple cyclopeptides; 13. More complex modified peptides; Epilogue; Appendix A. Abbreviations and their uses; Appendix B. A select bibliography and literature guide; Index

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