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About this book
Since the 1996 publication of "Translational Control", there has been fresh interest in protein synthesis and recognition of the key role of translational control mechanisms in regulating gene expression. This monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional 28 has a focus on a research topic of more specific interest. The result is an up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translational machinery of virus infection and disease. This book should be useful to students entering the field and an comprehensive resource for investigators of gene expression and its control.
Origins and Principles of Translational Control (M.B. Mathews, N. Sonenberg, and J.W.B. Hershey); Pathway and Mechanism of Initiation of Protein Synthesis (J.W.B. Hershey and W.C. Merrick); Protein Bioynthesis Elongation Cycle (W.C. Merrick and J. Nyborg); Comparative View of Initiation Site Selection Mechanisms (R.J. Jackson); Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes (A.G. Hinnebusch); Regulation of Ribosomal Recruitment in Eukaryotes (B. Raught, A.-C. Gingras, and N. Sonenberg); Translational Control of Developmental Decisions (M. Wickens, E.B. Goodwin, J. Kimble, S. Strickland, and M. Hentze); Viral Translational Strategies and Host Defense Mechanisms (T. Pe'ery and M.B. Mathews); Ribosomal Subunit Joining (T.V. Pestova, T.E. Dever, and C.U.T. Hellen); Physical and Functional Interactions between the mRNA Cap Structure and the Poly(A) Tail (A. Sachs); Translation Termination: It's Not the End of the Story (E.M. Welch, W. Wang, and S.W. Peltz); Genetic Approaches to Translation Initiation in Saccharomyces cerevisiae (T.F. Donahue); Double-stranded RNA-activated Protein Kinase PKR (R.J. Kaufman); Heme-regulated eIF2 alpha Kinase (J.-J. Chen); PERK and Translational Control by Stress in the Endoplasmic Reticulum (D. Ron and H.P. Harding); Regulation of Translation Initiation in Mammalian Cells by Amino Acids (S.R. Kimball and L.S. Jefferson); Translational Control during Heat Shock (R.J. Schneider); Translational Control by Upstream Open Reading Frames (A.P. Geballe and M.S. Sachs); Cellular Internal Ribosome Entry Site Elements and the Use of cDNA Microarrays in Their Investigation (M.S. Carter, K.M. Kuhn, and P. Sarnow); Translational Control and Cancer (J.W.B. Hershey and S. Miyamoto); Translational Control of Ferritin Synthesis (T.A. Rouault and J.B. Harford); Translational Control of TOP mRNAs (O. Meyuhas and E. Hornstein); S6 Phosphorylation and Signal Transduction (S. Fumagalli and G. Thomas); Control of the Elongation Phase of Protein Synthesis (C. Proud);Programmed Translational Frameshifting, Hopping, an